OBJECTIVE The use of endophenotypes, such as neurological soft signs (NSS), is advocated as one possible method to elucidate the heterogeneity of schizophrenia. Exploring the associations between NSS and specific illness symptoms has revealed some trends, although results have been conflicting. To date, such studies have been conducted largely on Caucasian populations and our pilot study repres...

The soft neurological signs (SNS) and minor physical anomalies (MPA) were studied in 107 adult schizophrenics. The sample consisted chronic (N=60) and acute (N=47) schizophrenic subtypes. The SNS were found more in chronic patients (p< .01). The most prevalent abnormalities in SNS were related to the sensory integration and motor co-ordination. The release reflexes were rare though they were en...

BACKGROUND Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting...