The neuroleptic malignant syndrome and the serotonin syndrome share many clinical features and may exist on a spectrum of the same disorder. The neuroleptic malignant syndrome, however, is an idiosyncratic drug reaction, whereas the serotonin syndrome is an effect of drug toxicity. Both syndromes present with varying degrees of mental status changes and autonomic instability. In general, patien...

INTRODUCTION Neuroleptic malignant syndrome is rare, but potentially fatal idiosyncratic reaction to antipsychotic medications. It is sometimes difficult to diagnose some clinical cases as neuroleptic malignant syndrome and differentiate it from the acute viral encephalitis. CASE REPORT We reported a patient diagnosed with acute psychotic reaction which appeared for the first time. The treatm...

A case of postoperative neuroleptic malignant syndrome is presented. A healthy 23-year-old male underwent a shoulder repair under uneventful fentanyl, halothane, nitrous oxide and oxygen anaesthesia. He received droperidol 5 mg IV and metoclopramide 10 mg IV intraoperatively to prevent postoperative nausea. Postoperatively, the patient developed autonomic instability, fever and generalized musc...

OBJECTIVE Neuroleptic malignant syndrome was induced by aripiprazole in a 12 1/2-year-old boy. The patient had a history of reactive airway disease, pervasive developmental disorder, and learning disability. METHOD The patient was interviewed and examined, and additional history was taken from the medical records. The Naranjo adverse drug reaction rating scale was applied. RESULTS The patie...

Neuroleptic malignant syndrome (NMS) is a life-threatening complication seen in psychiatric patients exposed to antipsychotic medications. NMS associated with medication dopamine antagonist action. The typical tetrad of symptoms includes fever, muscle rigidity, altered mental status and autonomic dysfunction. Acute pulmonary embolism one the major complications diagnosed neuroleptic symptoms. H...