Chronic cerebral hypoperfusion due to carotid artery stenosis is a major cause of vascular cognitive impairment and dementia (VCID). Bilateral (BCAS) in rodents well-established model VCID where most studies have focused on white matter pathology subsequent deficit. Therefore, our aim was study the implication adult hippocampal neurogenesis hypoperfusion-induced mice, its relationship with defi...

The cover image is based on the Editorial Adult neurogenesis in hippocampus by Gerd Kempermann et al., https://doi.org/10.1002/hipo.23525.

neuroimmune genes consistent with ethanol-induced neuroinflammation. In brain slice cultures, exogenous IL-1beta, TNFalpha and MCP1 reduce neurogenesis. Neutralizing antibodies to IL-1beta added to slice cultures increased neurogenesis and completely reversed ethanol inhibiton of neurogenesis. Exogenous IL-1 receptor antagonist, IL-1RIa, also blocked ethanol inhibition of neurogenesis, suggesti...

The excessive electrical activity of neurons is reported in many diseases including: Parkinson's disease, Alzheimer's disease, and Epilepsy. Electrical overactivity in hippocampus accelerates the depletion of neural stem cell (NSC) and impairs the neurogenesis in hippocampus. It is believed that neurogenesis in hippocampus improves the cognitive functions. In this experiment, we use kindled mod...

Hippocampal dentate gyrus is a focus of enhanced neurogenesis and excitability after traumatic brain injury. Increased neurogenesis has been proposed to aid repair of the injured network. Our data show that an early increase in neurogenesis after fluid percussion concussive brain injury is transient and is followed by a persistent decrease compared with age-matched controls. Post-injury changes...

Background & Aims: Neurogenesis in the adult mammal brain occurs throughout life. Adult neurogenesis has been clearly demonstrated in the sub granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. Pheromones that plays an essential role in the development of the central nervous system. The male pheromones are involved in regulating neurogenesis in both the olfactory bulb and hippocam...

Background:  Maternal sleep deprivation is known to reduce neurogenesis in the hippocampus during pregnancy. Also, it damages and impairs cognitive functions such as learning and memory in the neonates.  Objectives: Rosmarinus officinalis (rosemary) extract can play an important role in the treatment of cognitive impairments by inhibiting oxidative stress. This study aimed to investigate the r...

Experiencing chronic stress significantly increases the risk for depression. Depression is a complex disorder with varied symptoms across patients. However, feeling of sadness and decreased motivation, diminished pleasure (anhedonia) appear to be core most depressive pathology. Odorants are potent signals that serve critical role in social interactions, avoiding danger, consummatory behaviors. ...

Both social defeat stress and environmental enrichment stimulate adrenal glucocorticoid secretion, but they have opposing effects on hippocampal neurogenesis and mood. Hypothalamic-pituitary-adrenal axis dysregulation and decreased neurogenesis are consequences of social defeat. These outcomes are correlated with depressive states, but a causal role in the etiology of depression remains elusive...

Recent research demonstrates that neural stem cells divide throughout life and give rise to new neurons, a process known as neurogenesis. This article addresses two principal questions concerning alcohol and adult neurogenesis: To what extent are neurogenesis in the adult brain and the risk for alcoholism governed by similar factors? And, to what extent and through what mechanisms do alcohol us...