DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) has been shown to be involved in learning and memory impairments in Alzheimer disease and Down syndrome. As a homolog of Drosophila minibrain gene, DYRK1A also plays important roles in neurodevelopment; however, the function and regulatory mechanism of DYRK1A in neurodevelopment remain elusive. REST (RE1 silencing transcript...

OBJECTIVE To investigate the relationship between the complexity of sleep EEG time series and neurodevelopment for premature or full-term neonates. METHODS Nonlinear dynamical analysis of neonatal sleep EEG time series is used to compute the correlation dimension D2 which is an index of the complexity of the dynamics of the developing brain. The dimensional complexity is estimated using Theil...

In this paper abstractions of neurodevelopmental mechanisms of biological nervous systems are interpreted as changes in the structure, learning parameters and input data of artificial neural networks. A review of neurodevelopmental mechanisms reveals that structural changes follow a typical timeline. We propose it as part of an algorithmic model of neurodevelopment and early learning. We furthe...

Background and Aim Prenatal exposure to indoor air pollution (IAP) has been linked neurodevelopmental delay in toddlers. Changes DNA methylation (DNAm) have independently associated with both prenatal delayed neurodevelopment. Investigating DNAm as a mediator may help elucidate the biological pathways driving association between IAP delay. In this study, we aim identify differentially methylate...

BACKGROUND We investigate patterns of neurodevelopmental trajectories in infants, using a representative population, and identify risk factors that predict delayed growth. METHODS Participating infants (n = 952; 82.8% of the total sample) were assessed by Mullen Scales of Early Learning at seven time points, from 1 month to 24 months of age. Mothers were recruited in early pregnancy and data ...

BACKGROUND Retinopathy of prematurity (ROP) is an eye disease caused by an alteration in retinal vasculogenesis that may lead to partial or complete vision loss with a harmful impact in terms of neurodevelopment. The purpose of the present study was to determine the neurodevelopment in patients with type i retinopathy of prematurity treated with intravitreal bevacizumab. MATERIAL AND METHODS ...

Polychlorinated biphenyls (PCBs) and dioxins are persistent environmental pollutants. The effects of these pollutants on neurodevelopment in children have been assessed in longitudinal studies performed in areas with low-level contamination of PCBs and dioxins. Some of these studies have shown that the PCBs and dioxins induced adverse effects on the neurodevelopment of children. However, other ...

BACKGROUND Prenatal exposure to organophosphorous (OP) pesticides has been found to be associated with adverse effects on child neurodevelopment, but evidence on potential effects induced by both prenatal and postnatal OP exposure in infants is limited. OBJECTIVES Our aim was to investigate the associations of both prenatal and postnatal OP exposure with birth outcomes and infant neurodevelop...

BACKGROUND Environmental manganese exposure has been associated with adverse neurodevelopmental outcomes among school-aged children; yet, few studies have evaluated prenatal exposure. OBJECTIVES Our study examines associations between prenatal manganese concentrations and placental transfer of manganese with neurodevelopment in 224 2-y-old children residing near the Tar Creek Superfund Site. ...

BACKGROUND Despite advances in nutritional support and intensive care, preterm infants are at higher risk of compromised neurodevelopment. OBJECTIVE This study evaluated the contribution of total parenteral nutrition (PN) to compromised neurodevelopment after preterm birth. METHODS Preterm pigs were provided PN or enteral nutrition (EN) for 10 d. Neurodevelopment was assessed by observation...