spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...

Stem cells are undifferentiated cells that have the ability to convert to different types of cells and after dividing, they can produce their own cells or other cells. Axons of the retinal ganglion cells, from the optic nerve. These cells lose the ability to regenerate themselves before birth. Optic nerve degeneration can result from various causes including increased intraocular pressure, comp...

peripheral nerve injuries (pni) can lead to lifetime loss of function and disfigurement. different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. utilization of absorbable and non-absorb...

In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...

Peripheral nerves are organ-like structures containing diverse cell types to optimize function. This interactive assembly includes mostly axon-associated Schwann cells, but also endothelial cells of supporting blood vessels, immune system-associated barrier-forming the perineurium surrounding and protecting nerve fascicles, connective tissue-resident within intra-fascicular endoneurium inter-fa...

Peripheral nerve injury requires a long recovery period, and recovery, once attained, usually is incomplete. Inflammatory procedures may inhibit functional recovery after nerve injury and produce cell death in both the central nervous system and the peripheral nervous system. Since the glycyrrhiza glabra extract has anti-inflammatory effects, it could reduce the severity of injury. The aim of t...

objective(s) motor deficit and neuron degeneration is seen after nerve transection. the aim of this study is to determine whether a poled polyvinelidene fluoride (pvdf) tube with other supportive strategies can protect the neuronal morphology and motor function after sciatic nerve transaction in rats. materials and methods after transection of the left sciatic nerve in 60 male wistar rats (200-...

Strategies of Schwann cell (SC) transplantation to regenerate the peripheral nerve injury involves many limitations. Stem cells can be used as alternative cell sources for differentiation into SCs. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ecto-mesenchymal stem cells (OE-MSCs) derive...

Objective: The aim of this study is to investigate the neuroprotective effect chrysotoxine (CTX) on sevoflurane-treated nerve cells and uncover potential regulation mechanism. Methods: Nerve treated with sevoflurane CTX were subjected MTT apoptotic detection. Cell apoptosis oxidative stress detected by flow cytometry (FCM) ELISA assays. In addition, immunoblot assay was performed signaling path...

our previous studies have shown that median and ulnar nerve lesion induced calbindin (cb) immunoreactivity in some injured motoneurons in developing rats. motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of neuronal isoform of nitric oxide synthase (nnos). the present study investigated whether expression of cb and nicotinomid adenin dinucleot...