BACKGROUND Oxidative stress plays a crucial role in the development of drug induced nephrotoxicity. The study aimed to determine the nephroprotective and ameliorative effects of Carica papaya seed extract in paracetamol-induced nephrotoxicity in rats. OBJECTIVES To carry out phytochemical screening of Carica papaya, measure serum urea, creatinine and uric acid and describe the histopathologic...

OBJECTIVES To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. MATERIALS AND METHODS Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum at ...

Aim of the study is to investigate the Nephroprotective activity of ethanolic extract taken from Melia azadirachta leaves, against APAP (Acetaminophen) induced nephrotoxicity. The phytochemical screening was carried out on the leaf extracts of Melia azadirachta, revealed the presence of active ingredients such as Phytol, Squalene, Oleic Acid, 2-Piperidinone, N-[4-bromo-n-butyl]. Leaves of Melia...

In Tunisian folk medicine, several herbs are prescribed for reducing renal damage and to avoid kidney related complications. These can be of immense value in combating damage. this review, we provide a description the current literature on use indigenous as alternative medicine treating The aim review was collect information promising active phytoconstituents such organosulfur compounds, polyph...

This study was carried out to investigate the therapeutic role of the ethanolic extract of Pleurotus cornucopiae on sodium arsenite induced nephrotoxicity in rats. Sodium arsenite at the dose of 8 mg·kg–1 body weight orally caused renal damage in rats as manifested by the significant rise in serum levels of serum urea, uric acid and creatinine level compared with control. Ethanolic extracts of ...

conclusions in conclusion, we suggest that tq may be used as a prophylactic agent against nephrotoxicity, especially in instances of tubular injury. however, human-based studies are still needed. objectives in this study, we investigated the comparative nephroprotective effects of silymarin, n-acetylcysteine (nac), and thymoquinone (tq) in animal models (rats) in which we induced nephrotoxicity...

In total, 57 patients (31 males and 26 females) with diabetic nephropathy were studied on a comparative basis to observe the renoprotective effectiveness of eprosartan mesylate and lercanidipine. Eprosartan mesylate revealed a higher nephroprotective effect compared with lercanidipine at comparable antihypertensive effects of equivalent doses of both these preparations.

Mushrooms represent a major and untapped source of potent new pharmaceutical products. The antioxidant, antiinflammatory, antinociceptive, antimutagenic, anticarcinogenic, antitumour, hepatoprotective, nephroprotective and cardioprotective activities of the methanolic extract of Ganoderma lucidum (Fr.) P. Karst. collected from tropical South India were evaluated for the revalidation of its util...