Nephrogenic systemic fibrosis is a chronic, progressive condition that develops in some patients with renal impairment after exposure to gadolinium-based contrast agents used in magnetic resonance imaging. Thickening of the skin is typical, usually affecting the extremities. Visceral organs can also be affected. The diagnosis of the disease requires careful clinicopathological correlation. Trea...

Nephrogenic systemic fibrosis is a new, rare disease of unknown cause that affects patients with renal failure. Single cases led to the suspicion of a causative role of gadodiamide that is used for magnetic resonance imaging. This study therefore reviewed all of the authors’ confirmed cases of nephrogenic systemic fibrosis (n 13) with respect to clinical characteristics, gadodiamide exposure, a...

There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF). The pathogenesis of this entity remains unclear; however, our recent observations suggest a likely mechanism for the initial dermal manife...

Fibrosis is a pathologic process in which deposition of abnormal extracellular matrix by fibroblasts leads to the loss of normal tissue structure and function. In skin, fibrosis is associated with several diseases, including systemic sclerosis, localized scleroderma, nephrogenic systemic fibrosis, and keloid scars. Currently, effective targeted therapies to reverse or prevent fibrosis are lacking.