Hepatitis E virus (HEV) infections lead to tens of thousands of deaths annually, mostly in developing countries. Hepatitis E poses a significant threat to the health of expectant mothers, a well-noted epidemiologic feature of the disease, but the contribution of vertically transmitted HEV infection to fetal and neonatal morbidity and mortality has received limited attention. Evidence assembled ...

Hepatitis B infection during pregnancy can have serious consequences for both the mother and her infant. This study aimed to determine prevalence of hepatitis among pregnant women its effect on neonatal outcomes in a tertiary care hospital Pakistan. 120 were enrolled study, their demographic clinical data collected. The was 4.2% population. Infants born B-positive mothers more likely be prematu...

AIM Hepatobiliary scintigraphy is an integral part in the diagnostic work-up of the neonatal cholestasis syndrome. However, less than optimal specificity is its major disadvantage. Differentiation between biliary atresia and neonatal hepatitis is nearly impossible in some cases with poor hepatocellular function. 99mTc sestamibi (MIBI) is a cationic lipophilic agent which is a substrate of P-gly...

Aetiological factors were sought prospectively in 55 babies with extrahepatic biliary atresia, in 105 with neonatal hepatitis, and in 11 with intrahepatic biliary atresia, seen as a result of nearly complete ascertainment of these conditions in the State of Victoria between 1963 and 1974. In neonatal hepatitis infective causes were shown in 22 babies, galactosaemia in 6 and alpha1-antitrypsin d...

Each of the risk factors for human liver cancer (aflatoxin exposure, hepatitis B virus-associated liver injury, p53 loss, p53ser249 mutation, and male sex) also increases the incidence of hepatocellular carcinoma (HCC) in mouse models of hepatocarcinogenesis. Neonatal mice, partially hepatectomized adult mice, and p53-deficient mice each have a higher hepatocyte proliferation rate, are less abl...

hepatitis b is the most common cause of acute and chronic viral hepatitis in iran. it is the etiology of 70% of end-stage liver disease and hepatocellular carcinoma in the country. before the universal neonatal vaccination in iran (1992), the contact rate with hbv was about 30% and the hbs ag+ rate was about 3%. in 2009 the contact rate has declined to 18% and hbsag+ rate decreased to 2%. the e...

background liver is prone to different diseases including metabolic, congenital, infections, drug injuries, and malignancies. liver biopsy is an aggressive but definitive way to diagnose liver diseases. objectives the present study is designed to evaluate the results of liver biopsies in children referred to the pediatric gastroenterology department of nemazee hospital. materials and methods th...

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Background Infants of diabetic mothers (IDMs) have significantly greater risk for spontaneous abortion, stillbirth, congenital malformations and perinatal mortality and morbidity but whether maternal DM affects the neonatal innate immune system is unknown. We aimed to assess the immune response of infants of diabetic mothers (IDMs) with non-gestational DM for Hepatitis B vaccine and to compare ...