The increasing prevalence of ciprofloxacin-resistant Neisseria gonorrhoeae has required replacing inexpensive oral ciprofloxacin treatment with more expensive injectable ceftriaxone. Further, monitoring antimicrobial resistance requires culture testing, but nonculture gonorrhea tests are rapidly replacing culture. Since the strategies were similar in effectiveness (> 99%), we evaluated, from th...

Gonorrhea, the second most commonly reported notifiable disease, is an important cause of cervicitis, urethritis, and pelvic inflammatory disease. The selection of appropriate therapy for gonorrhea (i.e., safe, highly effective, single dose, and affordable) is complicated by the ability of Neisseria gonorrhoeae to develop resistance to antimicrobial therapies. This article reviews the key quest...

An antigen isolated from Neisseria gonorrhoeae protoplasm reacted well in a flocculation procedure with sera from 86% of the females and 68% of the males infected with gonorrhea; the reactions with sera from presumed noninfected individuals were approximately 12%.

BACKGROUND Gonorrhoeae, a sexually transmitted disease caused by Neisseria gonorrhea for which humans are the only natural host. The causative organism is highly adapted to the genital tract and often causing asymptomatic and undetected infection in females in which Acquisition of gonococcal infection late in pregnancy can adversely affect labor and delivery as well as the well-being of the fet...

The family Neisseriaceae consists of Gram-negative aerobic bacteria from fourteen genera (Bergey's 2001), including Neisseria, Chromobacterium, Kingella, and Aquaspirillum. The genus Neisseria contains two important human pathogens, N. gonorrhoeae and N. meningitidis. N. gonorrhoeae causes gonorrhea, and N. meningitidis is the cause of meningococcal meningitis. N. gonorrhoeae infections have a ...

The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of sexually transmitted infection gonorrhea. increased emergence gonorrhea infections worldwide, associated with surging resistance to antimicrobial treatments alarming. Antimicrobial (AMR) a global threat health and occur through various molecular mechanisms. This research aims identify therapeutic targets in N. gonor...

A 55-year-old heterosexual male presented to the emergency department with a symptomatology consistent with urethritis and Fournier's gangrene. Urethral swab and operative tissue cultures were positive for coagulase-negative Staphylococcus and an intracellular Gram-negative diplococcus. The latter was initially thought to be Neisseria gonorrhea; however, DNA sequencing technique confirmed it to...

Gonorrhea is a relatively common infection among men who have sex with men, but it is becoming more common in heterosexual people. It is caused by the bactera Neisseria gonorrhoeae . This infection is transmitted via unprotected anal, oral and vaginal sex and can quickly be treated with antibiotics, but, if left untreated, gonorrhea can lead to serious problems. Such problems can occur because ...

Patients were studied for lymphocyte transformation responses to a variety of Neisseria gonorrhoeae antigens and to a Neisseria catarrhalis sonicate. Cells from infected patients manifested significant uptake of tritiated thymidine in response to one or more gonococcal antigens. In some cases, deoxyribonucleic acid synthesis was so marked in lymphocytes not challenged by antigens in vitro that ...

The new superbug Neisseria gonorrhoeae has retained resistance to antimicrobials previously recommended for first-line treatment and has now demonstrated its capacity to develop resistance to the extended-spectrum cephalosporin, ceftriaxone, the last remaining option for first-line empiric treatment of gonorrhea. An era of untreatable gonorrhea may be approaching, which represents an exceedingl...