BACKGROUND AND OBJECTIVES In 2010, the Bioethics Committee of the American Academy of Pediatrics issued recommendations that pediatric hematopoietic stem cell donors should have an independent advocate. Formulating appropriate guidelines is hindered by the lack of prospective empirical evidence from families about the experience of siblings during typing and donation. Our aim was to provide the...

BACKGROUND The mechanisms responsible for the variable manifestations of chronic cutaneous graft-vs-host disease (cGVHD) are poorly understood. Localization of sclerotic-type chronic graft-vs-host disease to sites of skin injury (isomorphic and isotopic responses), a recognized phenomenon in morphea, suggests a potential common pathway between cGVHD and other sclerotic skin conditions. OBSERV...

by drawing blood through a heparin lock, patients can be protected from skin damages duo to repeated needle sticks. in addition, this procedure can assist to gain more precise results in laboratory test and to prevent further complications. probably, you have ever used a heparin lock in order to infusion of medicines but, it is possible that you never use of that for blood sampling. both two pr...

Lateral transmission of blood-borne diseases can occur when a single needle is used repeatedly to vaccinate livestock. Needle-free technology to vaccinate sheep without damaging the carcass, causing lesions, or leaving needle fragments, and eliciting a similar antibody response as traditional needle vaccinations, has been hampered due to variable wool length. Vaccine delivery, injection time, a...

Needle biopsy is an indispensable diagnostic tool in obtaining tumor tissue for diagnostic examination. Tumor cell seeding in the needle track during percutaneous needle biopsies has been reported for various types of cancers. The mechanical force of the biopsy both directly displaces the malignant cells and causes bleeding and fluid movement that can further disseminate cells. To prevent the r...

Skin makes an excellent site for drug and vaccine delivery due to easy accessibility, immuno-surveillance functions, avoidance of macromolecular degradation in the gastrointestinal tract and possibility of self-administration. However, macromolecular drug delivery across the skin is primarily accomplished using hypodermic needles, which have several disadvantages including accidental needle-sti...

Background: Infectious hospital waste, including needles and sharp instruments, is one of the most important causes needle sticks. Objectives: The study aimed to investigate factors affecting disposal special medical waste with sticks among healthcare workers in hospitals at Iran University Medical Sciences. Methods: This descriptive-analytical, retrospective, cross-sectional were done regardin...