Basic research and clinical applications of HIFU to treat many life-threatening diseases such as uterine fibroids, osteosarcoma, liver cancer, breast cancer, and many others have attracted broad interests in global medical communities (Nat Rev Cancer. 2005; 5(4): 321-327; Nature Reviews Drug Discovery. 2005; 4:255-260). HIFU has been considered as one of the most important developing technologi...

Necrosis refers to a spectrum of morphologic changes that follow cell death in living tissue, largely resulting from the progressive degradative action enzymes on lethally injured (cells placed immediately fixative are dead but not necrotic).

The interstitial fluid transport plays an important role in terms of its effect on the delivery of therapeutic agents to the cancerous organs. In this study, a comprehensive numerical simulation of the interstitial fluid transport establishing 3D models of tumor and normal tissue is accomplished. Different shapes of solid tumors and their surrounding normal tissues are selected, by employing th...

In this in vitro study, we investigated the efficacy of sodium hypochlorite (NaOCl) and calcium hydroxide (Ca(OH)2) in dissolving necrotic tissue and cleaning root canals. In the first part of the study, 0.5% NaOCl solution and Ca(OH)2 paste and solution were tested with samples of necrotic bovine muscle in different treatment modes and for different periods. The necrotic tissue was weighed bef...

We investigated the repair of femoral head necrosis with extensive necrotic lesions treated by high-degree posterior rotational osteotomy (HDPRO) in young adults and adolescents (mean age; 30.8 years) using magnetic resonance imaging (MRI). HDPRO was performed on 72 hips from 66 cases, and of those, 60 hips from 60 cases were included in this study for data analysis. All cases had extensive col...

Dissatisfaction with the final results of treatment patients acute pancreatitis prompts search for new methods diagnosis and therapy this disease. Having experience in surgical 201 various forms pancreatic necrosis, we came to conclusion that classification should reflect state parapancreatic cellular space. This is due following points. First, an extensive purulent-necrotic lesion retroperiton...

BACKGROUND AND OBJECTIVES Hypercholesterolemia is a key factor in the development of atherosclerosis. We sought to evaluate the relation between hypercholesterolemia and plaque composition in patients with coronary artery disease. SUBJECTS AND METHODS Study subjects consisted of 323 patients (mean 61.5 years, 226 males) who underwent coronary angiography and virtual histology-intravascular ul...

OBJECTIVES To assess the outcome of core decompression in the treatment of osteonecrosis of the femoral head related to the volume of necrotic bone measured according to a previously reported method. METHODS Twenty hips corresponding to strictly Ficat stage II underwent magnetic resonance imaging and the volume of necrotic bone was expressed as a percentage of the volume of the entire head me...

OBJECTIVES This study sought to determine the accuracy of 3-dimensional, quantitative measurements of coronary plaque by computed tomography angiography (CTA) against intravascular ultrasound with radiofrequency backscatter analysis (IVUS/VH). BACKGROUND Quantitative, 3-dimensional coronary CTA plaque measurements have not been validated against IVUS/VH. METHODS Sixty patients in a prospect...

BACKGROUND This study aimed to evaluate the relationship between cigarette smoking and coronary atherosclerotic burden, volume and composition as determined in-vivo by grayscale and virtual histology (VH) intravascular ultrasound (IVUS). METHODS AND RESULTS Between 2008 and 2011, (VH-)IVUS of a non-culprit coronary artery was performed in 581 patients undergoing coronary angiography. To accou...