To investigate whether HLA-A, -B, -C, and -DR alloantigen frequencies are different in diabetic patients with and without necrobiosis lipoidica diabeticorum we studied 37 insulin-dependent (Type I) diabetics, 15 with and 22 without necrobiosis, and 96 normal control subjects. Compared to controls Type I diabetics had increased frequencies of B8, CW3, and DR4 and decreased frequencies of DR5 and...

Introduction: Necrobiosis Lipoidica (NL) had no adequate treatment. Some case has been treated by different vascular lasers. Third generation pulsed dye lasers with a wavelength of 595 nm has been attempted. Their selectively destroys shallower ectatic blood vessels. Material and Methods: We used a 595 nm, Dermobeam 2000 ® laser (manufactured by Deka© MELA Calenzano, Italy), with a dynamic skin...

NL: necrobiosis lipoidica RA: rheumatoid arthritis INTRODUCTION Necrobiosis lipoidica (NL) is a rare, chronic granulomatous disease that affects the dermis with collagen degeneration. It can be associated with several conditions including diabetes mellitus, sarcoidosis, rheumatoid arthritis (RA), inflammatory bowel disease, autoimmune thyroiditis, and monoclonal gammopathy. NL typically develop...

5. Van Esso DL. Los padres frente a la vacunación. Vacunas. 2010;11:133--4. 6. Jiménez Gómez N, Ballester Martínez MA, Alcántara González J, Jaén Olasolo P. Koplik spots as a diagnostic clue in a case of measles. Med Clin (Barc). 2012;139:560. 7. Lefebvre N, Camuset G, Bui E, Christmann D, Hansmann Y. Koplik spots: a clinical sign with epidemiological implications for measles control. Dermatolo...