OBJECTIVES Continuous albuterol nebulization is generally administered at 2.5-20 mg/hr at most centers. We examined the effect of high-dose (75 or 150 mg/hr) albuterol on clinical variables in children with status asthmaticus. DESIGN Retrospective analysis of inpatient medical records and prospectively collected computerized PICU respiratory therapy database. SETTING Twenty-five-bed multidi...

A double-blind crossover study was performed to compare 4 . 8 mg salbutamol given by pressure-packed aerosol and intermittent positive-pressure breathing nebulization in chronic asthmatic patients. The two delivery techniques produced similar changes in respiratory function and pulse rates. Given equal effect, a high-dose pressure-packed aerosol would have advantages in cost and convenience ove...

The aim of this study was to evaluate the biopharmaceutical behavior of colistin methanesulfonate (CMS) with special focus on colistin presystemic formation after CMS nebulization in rats. CMS was administered (15 mg x kg(-1) of body weight) either intravenously for systemic pharmacokinetic studies (n = 6) or as an intratracheal nebulization for systemic pharmacokinetic studies (n = 5) or for C...

Objective: To compare the outcome of Salbutamol nebulization with normal saline (placebo) in transient tachypnea newborn.
 Study Design: Comparative prospective study.
 Place and Duration Study: Department Neonatal Medicine, Military Hospital Rawalpindi, from Jan 2017 to Mar 2018.
 Methodology: Sixty term neonates respiratory rate >60 breaths/min newborn score ≥4 were enrolled...

Our understanding of albuterol nebulization driven by helium-oxygen mixture (heliox) has matured with recent advances in clinical therapy, delivery systems, and understanding of dosing; this has led to substantial improvements in delivery as well as refinements of research protocols for asthma exacerbations. This review begins with heliox inhalation therapy and then addresses heliox as a drivin...

OBJECTIVE Endogenous and exogenous nitric oxide (NO) may have important antibacterial effects in patients with pneumonia. NO administration has been limited to the continuous inhalation of gas-phase NO (ie, inhaled NO [iNO]). Intermittent nebulization of NONOates, novel NO donors, may permit the continuous intrapulmonary delivery of NO. Thus, we assessed the effects of nebulized diethylenetetra...

Background: Acute bronchiolitis is a common lower respiratory tract infection in infants which results from inflammatory obstruction of the small airways, Respiratory Syncytial Virus (RSV) being the main etiological agent. Aim and Objectives: To compare the effectiveness of 3% HTS nebulization with 0.9% NS nebulization , In hospitalized children with acute bronchiolitis based on time for resolu...

Topical anesthesia for flexible bronchoscopy can be achieved in several ways like administration of an anesthetic agents by injecting through cricothyroid membrane,by giving drug lignocaine through Nebulization, 3}administering the drug through oral spray. Nebulization of lidocaine can achieve very satisfying anesthesia comparable to oral spraying with significant low plasma levels of the drug....