bstract—Simultaneous electrophysiology and confocal miroscopy were used to investigate purinergic neurotransmision at single smooth muscle cells (SMCs) in mouse isolated as deferens, and to explore the relationship between two igh-resolution P2X-receptor-mediated measures of per ulse ATP release: transient peaks in the first time derivative f the rising phase of excitatory junction potentials (...

PURPOSE Adenoviral keratoconjunctivitis is recognized as one of the major pathogens of ophthalmological nosocomial infection worldwide. N-Chlorotaurine (Cl-HN-CH(2)-CH(2)-SO(3)H, NCT) is the N-chloro derivative of the amino acid taurine, which is an oxidant produced by human granulocytes and monocytes during inflammatory reactions. Using conventional viral plaque assay, it was previously shown ...

Purpose. The aim of the study was to compare the risk of thyroid malignancy and efficacy of repeat FNA in patients with thyroid nodules diagnosed cytologically as benign lesion (BL) with features of chronic thyroiditis (BL-CT) and BL without CT features (BL-nCT). Methods. The analysis included 917 patients with BL-CT and 7046 with BL-nCT in the first FNA. Repeat biopsy was carried out in 787 pa...

The fungistatic and fungicidal activity of N-chlorotaurine (NCT), a long-lived oxidant produced by stimulated neutrophils, was investigated. Physiological concentrations (75-100 microM) of NCT showed clear fungicidal activity against a range of Aspergillus isolates. Moreover, killing by NCT was significantly increased in the presence of ammonium chloride, explained by the formation of monochlor...

INTRODUCTION A controversial aspect of breast cancer management is the use of sentinel lymph node biopsy (SLNB) in patients requiring neoadjuvant chemotherapy (NCT). This paper discusses the detection rate (DT) and false negatives (FN) of SLNB after NCT to investigate the influence of initial nodal disease and the protocols applied. METHODS Prospective observational multicenter study in women...

Recent studies indicate that nicastrin (NCT) and presenilins form functional components of a multimeric -secretase complex required for the regulated intramembraneous proteolysis of Notch and -amyloid (A ) precursor protein (APP). To determine whether nicastrin is required for proteolytic processing of Notch and APP in mammals and the role of nicastrin in presenilin/ -secretase complex assembly...

PURPOSE To determine the agreement between intraocular pressure (IOP) measurements using an automated non-contact tonometer (NCT), Goldmann applanation tonometer (GAT), and the ocular response analyzer (ORA) in subjects with primary congenital glaucoma (PCG). METHODS Twenty-nine eyes of 17 PCG patients underwent IOP measurements using NCT, GAT and ORA. Variables obtained by the ORA were corne...

PURPOSE The ability to accurately predict the likelihood of achieving breast conservation surgery (BCS) after neoadjuvant chemotherapy (NCT) is important in deciding whether NCT or surgery should be the first-line treatment in patients with operable breast cancers. MATERIALS AND METHODS We reviewed the data of 513 women, who had stage II or III breast cancer and received NCT and surgery from ...

Aim : To compare IOP measurements using GAT and NCT in different IOP ranges (<10, ≥10-25 mm Hg and > 25 mm Hg) and evaluate the effect of CCT on IOP measurements by these techniques. Materials and Methods: IOP was measured by NCT followed by GAT in 188 eyes of 100 glaucoma patients attending glaucoma clinic at Chaithanya Eye Hospital , Trivandrum by a single observer. Mean of three consecutive ...

The original pink-eyed dilution (p) on chromosome 7 is a very old spontaneous mutation in mice. The oculocutaneous albinism II (Oca2) gene has previously been identified as the p gene. Oca2 transcripts have been shown to be absent in the skin of SJL/J mice with the original p mutant allele (Oca2(p)); however, the molecular genetic lesion underlying the original Oca2(p) allele has never been rep...