Adult T-cell leukaemia/lymphoma (ATL) is an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukaemia virus (HTLV)-1. The identification of new molecular targets for ATL prevention and treatment is desired. SIRT1, a nicotinamide adenine dinucleotide(+) -dependent histone/protein deacetylase, plays crucial roles in various physiological processes, including...

PURPOSE OF REVIEW Neonatal corneal opacification (NCO) describes the loss of corneal transparency at or soon after (<4 weeks) birth. Historically, the literature is strewn with terminology that has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan for, accurate genotype-phenotype correlation of and a better understanding of the entities that present i...

The netCDF Operator (NCO) software facilitates manipulation and analysis of gridded 2 geoscience data stored in the self-describing netCDF format. NCO is optimized to efficiently 3 analyze large multi-dimensional datasets spanning many files. Researchers and data centers 4 often use NCO to analyze and serve observed and modeled geoscience data including satel5 lite observations and weather, air...

Standard structural methods for the assessment of glaucoma, such as the planimetry of stereo color photographs of the optic disc, involve a subjective component either by the patient or examiner and suffer from poor reproducibility. Spectral-domain optical coherence tomography (SD-OCT) provides a 3-D, cross-sectional, microscale depiction of biological tissues. Given the wealth of volumetric in...

Measurement-based optimization schemes have been developed to deal with uncertainty and process variations. One of the methods therein, labeled NCO tracking, relies on appropriate parameterization of the input profiles and adjusts the corresponding input parameters using measurements so as to satisfy the necessary conditions of optimality (NCO). The applicability of NCO-tracking schemes has bee...

In order to determine the suitability of varieties for the Pongola area, two trials were established at the SASA Experiment Substation at Pongola, one harvested every spring and the other every autumn. Random samples of cane stalks were taken prior to harvesting and the ERS % C was determined. Using these data it was possible to study the variation in ERS % C with crop age and time of year. It ...

Field trials were used to investigate the phytotoxicity of foliar sprays of 2,4-D amine to sugarcane. Yield losses of variety NCo 376 resulted from band sprays when 3,3 kg ae/ha was sprayed onto plant or ratoon cane which had unfurled three or more leaves per shoot. The greater the foliar development of the crop at the time of spraying, the greater was the resulting crop loss. At similar stages...

Plans for NextGen include the implementation of Net-Centric Operations (NCO) as the underlying mechanism to more effectively manage National Air Transportation System (NAS) resources. NCO mechanisms will provide the means for all agents operating in the NAS to self-synchronize in the presence of changing situations and probabilistic forecasts. Applications of NCO in other domains (e.g. military...

[RhCl(NCO)(nbyl)(PR3)] (nbyl = σ-norbornenyl; NCO = quinoline-8-acyl; R = p-F-C6H4) (1) has been synthesized by the reaction of [Rh(nbd)Cl]2 (nbd = norbornadiene) with 2 equivalents of NCHO (quinoline-8-carbaldehyde) and 2 equivalents of PR3. Compound 1 has been fully characterized in solution and also in the solid state by X-ray diffraction. Compound 1 shows low stability in solution and under...

Click reactions have provided access to an array of remarkably complex polymer architectures. However, the term "click" is often applied inaccurately to polymer ligation reactions that fail to respect the criteria that typify a true "click" reaction. With the purpose of providing a universal way to benchmark polymer-polymer coupling efficiency at equimolarity and thus evaluate the fulfilment of...