نتایج جستجو برای: ncl
تعداد نتایج: 963 فیلتر نتایج به سال:
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is essential for EBV episome maintenance, replication, and transcription. These effects are mediated by EBNA1 binding to cognate oriP DNA, which comprise 20 imperfect copies of a 30-bp dyad symmetry enhancer and an origin for DNA replication. To identify cell proteins essential for these EBNA1 functions, EBNA1 associated cell proteins were immu...
Metallic glasses exhibit fast mechanical relaxations at temperatures well below the glass transition, one of which shows little variation with temperature known as nearly constant loss (NCL). Despite important implications this phenomenon to deformation, origin relaxation is unclear. Through molecular dynamics simulations a model metallic glass, Cu64.5Zr35.5, we implement dynamical spectroscopy...
Dementia in children or young adults is most frequently caused by neuronal ceroidlipofuscinoses (NCL), a group of incurable lysosomal storage disorders linked by the accumulation of a characteristic intracellular storage material and progressive clinical deterioration, usually in combination with visual loss, epilepsy, and motor decline. The clinical characteristics can vary and the age at dise...
Abstract Many empirical equations have been proposed in the past to predict parameters of one-dimensional normal consolidation line (1D-NCL) for soils. However, applications these are limited specific range pressure and plasticity General 1D-NCL large soils presented this study. It is assumed that has up three slopes start at different stresses depending on liquid limit (LL) The 59 a LL (19–520...
Heterozygous mutations in the GRN gene lead to progranulin (PGRN) haploinsufficiency and cause frontotemporal dementia (FTD), a neurodegenerative syndrome of older adults. Homozygous GRN mutations, on the other hand, lead to complete PGRN loss and cause neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease usually seen in children. Given that the predominant clinical and pathologica...
BACKGROUND Reprogramming of somatic cells for derivation of either embryonic stem (ES) cells, by somatic cell nuclear transfer (SCNT), or ES-like cells, by induced pluripotent stem (iPS) cell procedure, provides potential routes toward non-immunogenic cell replacement therapies. Nucleolar proteins serve as markers for activation of embryonic genes, whose expression is crucial for successful rep...
Fungal Keratitis (FK) is the main corneal infection that is resistant to antifugi drugs. Exploring new agent will be important for the drug resistance and new infectious diseases. All-Trans-Retinoic Acid (ATRA), a bioactive derivative of vitamin A, is immunoregulatary and anti-inflammation agent by decreasing the expression of the pro-inflammatory cytokines and increasing the expression of anti...
Abstract: A self-timed ring using NULL Convention Logic (NCL) is presented. Analytical method to evaluate the speed of NCL rings has been developed. The analytical predictions are verified by Synopsys simulation. Excellent agreement between the theoretical predictions and simulation results is obtained. The analysis leads to speed optimization of a 24-bit NCL divider to achieve a throughput of ...
3/4-Mercaptobenzyl sulfonates were investigated as aryl thiol catalysts for native chemical ligation (NCL). Whilst catalysing NCL processes at a similar rate to 4-mercaptophenyl acetic acid (MPAA), the increased polarity and solubility of 3-mercaptobenzyl sulfonate in particular may favour its selection as NCL catalyst in many instances.
how to cite this article: schulz a, kohlschütter a. ncl disorders: frequent causes of childhood dementia. iran j child neurol. 2013 winter;7(1):1-8. abstract dementia in children or young adults is most frequently caused by neuronal ceroidlipofuscinoses (ncl), a group of incurable lysosomal storage disorders linked by the accumulation of a characteristic intracellular storage material and progr...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید