نتایج جستجو برای: nasopharyngeal carcinoma npc
تعداد نتایج: 403499 فیلتر نتایج به سال:
Nasopharyngeal carcinoma (NPC) is a malignant that appears in the epithelial lining of nasopharyngeal mucosa. Genetic predisposition, environmental risk factors, nutritional and Epstein-Barr virus (EBV) infection are main factors for NPC. virus, human cancer-associated present more than 90% people worldwide. Latent Membrane Protein 1 (LMP1) has been identified as converting oncoprotein. LMP1 wa...
Background: The aim of this study was to analyze the prognostic factors for nasopharyngeal carcinoma (NPC) patients with distant metastasis after intensity-modulated radiotherapy (IMRT), and provide a further basis clinical treatment options.
Recent studies demonstrated that long non-coding RNAs (lncRNAs) deregulated in many cancer tissues including nasopharyngeal carcinoma (NPC) and had critical roles in cancer progression and metastasis. In this study, we aimed to assess a lncRNA LINC01420 expression in NPC and explore its role in NPC pathogenesis. Our research revealed that the expression level of LINC01420 in NPC tissues were hi...
Nasopharyngeal carcinoma (NPC) is a polygenic disease related to a variety of factors. With the development of the microRNAs (miRNAs) technique, researchers found a close link between miRNAs and NPC. Differentially expressed miRNAs exist in NPC and normal nasopharyngeal tissues; radiotherapy and chemotherapy also affect the expression of miRNAs in NPC tissues. Further studies showed that dysreg...
Our previous study demonstrated that the NGX6b gene acts as a suppressor in the invasion and migration of nasopharyngeal carcinoma (NPC). Recently, we identified the novel isoform NGX6a, which is longer than NGX6b. In this study, we first found that NGX6a was degraded in NPC cells and that this degradation was mediated by ezrin, a linker between membrane proteins and the cytoskeleton. Specific ...
Aim: The exact immunopathogenesis of Epstein-Barr virus (EBV)associated nasopharyngeal carcinoma (NPC) remains unclear. The aim of the present study was to assess the expression of CD4, CD8, and MHC class I molecules in NPC. Method: Biopsies were obtained from patients with NPC as well as the Epstein Barr virus (EBV)-seronegative patients as a control. Nasopharyngeal carcinoma patients were cla...
Squamous cell carcinoma antigen 1 (SCCA1) is implicated in the growth, differentiation and metastasis of squamous cell carcinoma. Previously we found that SCCA1 protein level was lower in nasopharyngeal carcinoma (NPC) than in nasopharyngeal epithelial tissue. This study aimed to investigate the mechanism by which SCCA1 expression is downregulated in NPC. Four NPC cell lines including CNE1, CNE...
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck region, especially among those of Chinese origin. NPC has multifactorial aetiologies including genetic susceptibility, consumption of food with high salt content, and the Epstein-Barr virus. The primary tumour usually arises from the lateral walls of the nasopharynx and is characterized by a rich sub-muco...
PURPOSE The methylation of high-in-normal-1 (HIN-1) gene promoter in undifferentiated nasopharyngeal carcinoma (NPC) is studied. EXPERIMENTAL DESIGN The methylation status of HIN-1 in NPC cell lines, primary NPC, paired nasopharyngeal swabs, paired throat-rinsing fluid, and paired peripheral blood was assessed by methylation-specific PCR assay. The relationship between HIN-1 promoter methylat...
Exosomes are nanosized (30-100nm) membrane microvesicles secreted through a complex cellular process. Exosomes contain a variety of bioactive molecules, such as proteins, microRNAs(miRNAs or miRs) and long non-coding RNAs (lncRNAs), playing an important role in the cell-to-cell substance transportation and signal transduction. Nasopharyngeal carcinoma-related exosomes (NPC-Exo) have been identi...
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