نتایج جستجو برای: naringin

تعداد نتایج: 644  

2010
Atanu Singha Roy Debi Ranjan Tripathy Angshuman Chatterjee Swagata Dasgupta

The interaction of naringin with bovine serum albumin has been performed using fluorescence, circular dichroism and fourier transform infrared spectroscopy in 20 mM phosphate buffer of pH 7.0 as well as molecular docking studies. The changes in enthalpy (ΔH°) and entropy (ΔS°) of the interaction were found to be +18.73 kJ/mol and +143.64 J mol K respectively, indicating that the interaction of ...

2013
Ranjana Das Amrita Dutta Chiranjib Bhattacharjee

Present study has been under taken to evaluate the nutraceutical significance of bioflavonoid naringin, from pummelo fruit peel. Bioflavonoids were selectively extracted from the pummelo fruit peel meal without any interference of pectin using aqueous ethanol as solvent. Significant naringin content of 0.440.02g/100g of peel was found in fruit peel meal. For selective fractionation and concent...

2017
Hongbo Shi Honglin Shi Feng Ren Dexi Chen Yu Chen Zhongping Duan

A previous study has demonstrated that Ganshuang granule (GSG) plays an anti-fibrotic role partially by deactivation of hepatic stellate cells (HSCs). In HSCs activation, mammalian target of rapamycin (mTOR)-autophagy plays an important role. We attempted to investigate the role of mTOR-autophagy in anti-fibrotic effect of GSG. The cirrhotic mouse model was prepared to demonstrate the anti-fibr...

2016
Guo-Yong Yu Gui-Zhou Zheng Bo Chang Qin-Xiao Hu Fei-Xiang Lin De-Zhong Liu Chu-Cheng Wu Shi-Xin Du Xue-Dong Li

Naringin is a major flavonoid found in grapefruit and is an active compound extracted from the Chinese herbal medicine Rhizoma Drynariae. Naringin is a potent stimulator of osteogenic differentiation and has potential application in preventing bone loss. However, the signaling pathway underlying its osteogenic effect remains unclear. We hypothesized that the osteogenic activity of naringin invo...

Objective(s): Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation. Materials and Methods: Annexin V-FITC assay and MTT assay ...

Journal: :Nutrition and cancer 2008
Edward G Miller Jason J Peacock T Campbell Bourland Samuel E Taylor John M Wright Bhimanagouda S Patil Edward G Miller

Six citrus flavonoids were tested for antineoplastic activity. The hamster cheek pouch model was utilized, and the solutions of the flavonoids (2.0-2.5%) and the solution of the carcinogen, 7,12-dimethylbenz[a]anthracene (0.5%), were applied topically to the pouches. The pouches of the positive controls were treated with the solvent used to dissolve the flavonoids and the solution of the carcin...

Journal: :Indian Journal of Pharmaceutical Sciences 2022

To investigate the effect of naringin on fibrosis transforming growth factor-beta 1 induced human embryonic lung fibroblasts MRC-5 and its potential mechanism. cells were treated with different concentrations naringin, 5 ng/ml 2 μmol/l nuclear factor kappa B activator phorbol myristate acetate. The experiment was divided into blank group, 1+naringin group 1+naringin+phorbol acetate group. 3-(4,...

2017
Dafei Xie Peiwen Yuan Dong Wang Hua Jin Hui Chen

The effects of naringin on the expression of miR-19b and cell apoptosis were investigated in the human hepatocellular carcinoma cell line HepG2. HepG2 cells were treated with varied concentrations of naringin. The effects of naringin on the proliferation of HepG2 cells were observed by an MTT assay, morphological changes of cells were observed by an inverted microscope, cell apoptosis was detec...

Journal: :Molecules 2011
Marcelo L Santos Daniela O Toyama Simone C B Oliveira Camila A Cotrim Eduardo B S Diz-Filho Fábio H R Fagundes Veronica C G Soares Ricardo Aparicio Marcos H Toyama

In this work we have characterized the action of the naringin, a flavonoid found in grapefruit and known for its various pharmacological effects, which include antioxidant blood lipid lowering and anticancer activity, on the structure and biochemical activities of a secretory phospholipase A (sPLA2) from Crotalus durissus cascavella, an important protein involved in the releasinge of arachidoni...

Journal: :Molecular medicine reports 2015
Zhonghua Qi Yinghui Xu Zhanhua Liang Sheng Li Jie Wang Yi Wei Bin Dong

Naringenin is a flavonoid polyphenolic compound, which facilitates the removal of free radicals, oxidative stress and inflammation. The present study aimed to obtain a better understanding of the effects of curcumin on the regulation of diabetes‑associated cognitive decline, and its underlying mechanisms. An experimental diabetes mellitus (DM) rat model was induced by streptozoticin (50 mg/kg)....

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