Femtosecond fluorescence upconversion experiments were performed on the naturally occurring medicinal pigment, curcumin, in anionic, cationic, and neutral micelles. In our studies, the micelles are composed of sodium dodecyl sulfate (SDS), dodecyl trimethyl ammonium bromide (DTAB), and triton X-100 (TX-100). We demonstrate that the excited-state kinetics of curcumin in micelles have a fast (3-8...

A new class of 'soft' particles, micelles, is detected electrochemically via 'nano-impacts' for the first time. Short, sharp bursts of current are used to indicate the electrical contact of a single CTAB (cetyltrimethylammonium bromide) micelle with an electrode via the oxidation of the bromide content. The variation in CTAB concentration for such 'nano-impact' experiments shows that a signific...

Conventional therapies of cancer cause serious side effects, systemic toxicity, poor quality of life of patients, accompanied with tumor resistance and recurrence which discourage their long term use. Therefore, highly precise anticancer therapies with minimal side effects are needed to be identified. Curcumin’s widespread availability, safety, low cost and anticancer activity justify its devel...

Terbium(III) was coordinated to four novel 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) amphiphilic bisamide ligands. The complexes were assembled into mono-disperse micellar nano-aggregates and for the first time Tb(III) has been evaluated as a single lanthanide negative bimodal contrast agent for MRI/OI. The complexes show characteristic Tb(III) emission with quantum yields...

Inflammatory disorders alone or as a consequence of neurological disease affecting patients in life. Experimental models of inflammation are use to evaluate the production of inflammatory mediators at site of inflammation. Curcumin is one of the flavonoids possesses potent anti-inflammatory activity. However, because of low water solubility curcumin, its clinical application has been limited. T...

block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. in this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. the factor fphil is defined as the ratio of the number of hydroph...

Combinational chemotherapy is often used to prevent drug induced resistance in cancer. The aim of this work is to test whether the co-delivery of drugs within one nanoparticle can result in increased synergistic effects of both drugs. Therefore, a micelle system with two different compartments, one for the drug curcumin and one for the conjugation of platinum drugs was designed. A triblock copo...

Objective(s): Aluminum phosphide (AlP) is commonly used pesticide which could cause poisoning mainly through the induction of oxidative stress. The present study aimed to evaluate the effects of nano-curcumin and curcumin on the oxidant and antioxidant system in the liver mitochondria using AIP-induced toxicity model.Materials and Methods: In this study, 36 male albino Wistar rats were ra...

in this work, we report on the synthesis of superparamagnetic iron oxide nanoparticles at room temperature using microemulsion template phase consisting of cyclohexane, water, ctab as cationic surfactant and butanol as a cosurfactant. surface modification have been carried out by using poly(ethyleneglycol) (peg). the structure,morphology, and magnetic properties of the products were characteriz...