The misuse of anabolic androgenic steroids has in several reports been associated with effects resulting in altered behavior. This study used the Morris water maze task to investigate the effect of high doses of the anabolic androgenic steroid nandrolone on spatial learning and memory in male rats. During the experiment, we observed a significantly impaired Morris water maze performance in the ...

introduction: the effect of regular exercise in decreasing the incidence of heart diseases is well known. the abuse of anabolic androgenic steroids (aas) has been associated with cardiovascular disorders. uncoupling proteins (ucps) transport protons across the inner mitochondrial membrane thereby proton gradient can be diminished by the action of ucps. this process will result in the uncoupling...

Anabolic-androgenic steroid (AAS) abuse is associated with multiple neurobehavioral disturbances. The sites of action and the neurobiological sequels of AAS abuse are unclear at present. We investigated whether two different AASs, nandrolone and methandrostenolone, could affect neuronal survival in culture. The endogenous androgenic steroid testosterone was used for comparison. Both testosteron...

Behavioral perturbations associated with nandrolone decanoate abuse by athletes and adolescents may be attributed to oxidative stress and inflammation. However, the underlying mechanisms are not yet fully explored. On the other hand, the natural antioxidant lipoic acid can pass the blood brain barrier and enhance Nrf2/HO-1 (nuclear factor erythroid-2 related factor 2/heme oxygenase-1) pathway. ...

Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon release and myotendinous retraction cause alterations in lipid related gene expression leading to fa...

The effect of anaerobic physical training and nandrolone treatment on the sensitivity to phenylephrine in thoracic aorta and lipoprotein plasma levels of rats was studied. Sedentary and trained male Wistar rats were treated with vehicle or nandrolone (5 mg/kg IM; twice per week) for 6 weeks. Training was performed by jumping into water (4 sets, 10 repetitions, 30-second rest, 50% to 70% body we...

The relationship of strength to muscle area was used to assess change in muscle quality after anabolic interventions. Study 1: asymptomatic human immunodeficiency virus-positive men (39 +/- 9 yr) were randomized to nandrolone (600 mg/wk) +/- resistance training (RT). Study 2: older healthy men (72 +/- 5 yr) were randomized to oxandrolone (20 mg/day) or placebo. Maximum voluntary strength was de...

conclusions the findings suggest that chronic coadministration of nandrolone with moderate-intensity endurance exercise facilitates the vf occurrence in rat. complementary studies are needed to elucidate the involved mechanisms of this abnormality. results nandrolone, exercise, and their combination were associated with heart hypertrophy. exercise could prevent the incremental effect of nandrol...

Nandrolone or 19-nortestosterone, or 17ß-hydroxy-19-nor-4-androsten-3-one, has been one of the most abused anabolic steroids and doping practices are increasing, as revealed by numerous positive cases during the last 5 years in various sports. The drug accelerates muscle growth by an anabolic effect. Athletes use nandrolone because it has been claimed that it increases lean body mass, increases...