This study investigated the action of 5-HT receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three 1A antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant |30% reduction in the number of BrdUimmunoreactive cells in the dentate gyrus. This suggests that 5-HT receptor activity is important during naturally occurring cell 1A proliferati...

The mechanisms for the vascular actions of vasodilatory b-blockers remain undetermined. For some kinds of b-blockers, the involvement of nitric oxide (NO) has been suggested. We studied the effects of vasodilatory b-blockers on renal perfusion pressure (RPP) and NO release in the rat kidney. Infusion of bopindolol, celiprolol, and nebivolol caused a dose-dependent reduction in RPP and an increa...

Previous research in our laboratory suggests that serotonin (5-HT) neurotransmission mediates the expression of cocaine-induced convulsions. The role of 5-HT in mediating this toxic effect of cocaine appears to be due to activation of 5-HT(2) receptors, because cocaine-induced convulsions are blocked by the 5-HT(2) antagonists cinanserin, ketanserin, and pirenperone. The present study utilized ...

Corrigendum: CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors Jing Zhang, Cheng-Yun Cai, Hai-Yin Wu, Li-Juan Zhu, Chun-Xia Luo & Dong-Ya Zhu Scientific Reports 6:29551; doi: 10.1038/srep29551; published online 12 July 2016; updated on 24 February 2017 This Article contains an error in Figure 4A, where the LV-VP16-CREB-GFP ...

The effect of some serotonin receptor antagonists was investigated on the body temperature of male mice. These antagonists produced significant reductions of body temperature in methamphetamine-induced hyperthermic male mice. Thus, the hyperthermia induced by methamphetaminc (11 ~tmol/kg,i.p.) was antagonized by the previous i.p. administration of 1.06 gmol/kg NAN-190 (5-HTIA receptor antagonis...

In Parkinson's disease (PD), prolonged exposure to L-3,4-dihydroxyphenylalanine (L-DOPA) results in motor fluctuations, such as the on-off phenomenon, and L-DOPA-induced dyskinesia. Previously, we found that activation of 5-HT(1A) in the substantia nigra pars compacta (SNc) decreased catalepsy in parkinsonian rats. In the current investigation, we attempted to evaluate the effect of buspirone o...

PURPOSE Several evidences show that serotonergic neurons play a role in the regulation of movements executed by the basal ganglia. Recently we have reported that single dose of buspirone improved 6-hydroxydopamine (6-OHDA) and haloperidol-induced catalepsy. This study is aimed to investigate effect of chronic intraperitoneal (i.p.) administration of buspirone on 6-OHDA-induced catalepsy in male...

The taiep rat is a myelin mutant that shows a disorganized sleep-wake cycle and immobility episodes (IEs) when the animals are gripped at the base of the tail. During IEs electroencephalographic recordings show a rapid eye movement (REM) sleep-like pattern. These alterations are quite similar to those reported in narcolepsy-cataplexy. Pharmacologically, systemic administration of alpha(2) adren...

Fasting gastric fundus tone is maintained by continuous cholinergic input. 5-Hydroxytryptamine-1 (5-HT1) receptor activation decreases gastric fundus tone in humans. Whether this fundus-relaxing effect is mediated via inhibition of cholinergic input or via activation of a nitrergic pathway is unknown. The aim of the present study was to determine the effect of nitrergic inhibition on feline gas...