This study was designed to assess the effect of five common anticonvulsant drugs on naloxone-precipitated withdrawal syndrome in morphine-dependent mice. Male mice (25-35 g) were made dependent by increasing doses of morphine (30-90 mg/kg). At least three doses of phenytoin, carbamazepine, sodium valproate, lamotrigine and topiramate were injected i.p. to morphine-dependent mice 45 min prior to...

background: matricaria chamomilla (mc) contains flavonoids such as apigenine which exerts benzodiazepine-like activity, therefore it may be helpful for morphine withdrawal syndrome treatment. in this study the effects of peripheral (ip) injection of mc hydroalcoholic extract was investigated on morphine withdrawal syndrome signs in rats. material &methods;: 24male wistar rats (200-250gr) were a...

introduction: morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. the present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and repeated doses morphine administrated rats. methods: male wistar rats were subjected to morphine consumption with single or frequent dose protocols. ...

introduction: there are some evidences that the matricaria recutita extract has sedative effects and relieves symptoms of morphine withdrawal syndrome. symptoms of this syndrome are due to increased expression of fos transcription factor in brain. in this study the effect of chronic hydro alcoholic extract (30 mg/kg) of matricaria recutita on jumping behavior and expression of fos transcription...

Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded th...

BACKGROUND Glycogen-synthase kinase 3 (GSK3) is involved in many signaling pathways and is associated with a host of high-profile pathophysiological states. However, its role in morphine tolerance, especially naloxone-precipitated withdrawal syndrome, has not been well investigated. The present study was undertaken to study the role of GSK3 in chronic morphine exposure. METHODS Adult male Spr...

Background: Herbal medical compounds and their major constituent have been used in the management and treatment of opioid withdrawal syndrome and pain. This study was carried out to clarify the effect of curcumin, the major compound of turmeric, on morphine withdrawal syndrome in mouse model and its possible mechanisms of pain relieving activity by assessing in writhing test as a model of visce...

BACKGROUND Thymus species are well known medicinal plants which the previous studies suggested the involvement of the opioid system in them. OBJECTIVES This study aimed to investigate the effects of methanolic extract and essential oil of aerial parts of Thymus daenensis (TD), an endemic aromatic medicinal plant of Iran, on morphine withdrawal syndrome in mice. MATERIALS AND METHODS Experim...