نتایج جستجو برای: nadph

تعداد نتایج: 21368  

Journal: :Angewandte Chemie 2021

Die nachhaltige Abscheidung und Umwandlung von Kohlendioxid (CO2) ist ein Schlüssel für das Erreichen einer kreislauforientierten Kohlenstoffwirtschaft. Bioelektrokatalyse verspricht, dieses Ziel zu erreichen. funktionale Integration CO2-fixierenden Enzymen in Materialien zur Elektrodenfunktionalisierung die Elektrosynthese stereochemisch komplexer Moleküle muss jedoch erst noch demonstriert we...

Journal: :Chemcatchem 2022

Nicotinamide cofactor-dependent oxidoreductases have become a valuable tool for the synthesis of high value chiral compounds. The feasibility biocatalytic processes involving these enzymes stands and falls with efficiency regeneration cofactors. In this study, we describe novel NADPH method based on natural thioredoxin electron delivery system. Thioredoxin 1 (Trx1) reductase (TR) from Thermus t...

فتاحی, مریم , مجیدزاده, سولماز, نوبخت, ملیحه, طباطبایی, پروانه , میرصمدی, منصور ,

    NO is a free radical that regulates a variety of developmental modulation processes. NO is synthesized by NOS and it acts as a neurotransmitter, neuromodulator or second messenger molecule in the central nervous system. Since NO production may be different before or after birth, the expression of neuronal nitric oxide synthase was examined and analysized during the development of rat optic ...

Journal: :Plant physiology 1988
L A Kleczkowski C V Givan J M Hodgson D D Randall

Protoplasts purified from pea (Pisum sativum L.) leaves were lysed and fractionated to assess the subcellular distribution of NADPH-dependent hydroxypyruvate reductase (NADPH-HPR) activity. Rate-zonal centrifugation and sucrose-gradient experiments demonstrated that most (about 70%) of the NADPH-HPR activity was located in the supernatant or cytosol fraction. Detectable, but relatively minor ac...

Journal: :Frontiers in bioscience 2011
Yingxin Ma Heyu Chen Cuiping Zhao Weiliang Xia Weihai Ying

NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) plays pivotal roles in antioxidation and reductive biosynthesis. However, the effect of NADPH treatment on cell survival is unknown. In this study, we determined the effect of NADPH treatment on the survival of glioma cells. Treatment of C6 glioma cells with as low as 1 μM NADPH for 24 hrs induced a significant decrease in the su...

Journal: :Biological & pharmaceutical bulletin 2009
Yuki Ogasawara Masayo Funakoshi Kazuyuki Ishii

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the principal source of reducing power in numerous processes of physiological importance. We examined the influence of oxidative stress on the relative amounts of NADPH in human red blood cells (RBCs). To determine the homeostasis of the NADPH existing in the reduced form following oxidation, we developed an improved method for meas...

Journal: :iranian journal of allergy, asthma and immunology 0
mohsen badalzadeh immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran fatemeh fattahi immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran mohammad reza fazlollahi immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran shaghayegh tajik immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran mohammad hassan bemanian department of pediatrics, division of allergy and immunology, shahid sadoughi hospital, school of medicine, shahid sadoughi university of medical sciences, yazd, iran fatemeh behmanesh allergy research center, ghaem hospital, school of medicine, mashhad university of medical sciences, mashhad, iran

chronic granulomatous disease (cgd), a rare inherited primary immunodeficiency disorder,  is  caused  by  mutation  in  any  one  of  the  genes  encoding  components   of nicotinamide adenine dinucleotide phosphate (nadph)-oxidase enzyme. ncf2 gene (encoding p67-phox component) is one of them and its mutation is less common to cause cgd (around 5-6%). here, we assessed mutation analysis of ncf...

Journal: :Planta medica 2013
Philipp A Kofler Haymo Pircher Susanne von Grafenstein Thomas Diener Monika Höll Klaus R Liedl Karsten Siems Pidder Jansen-Dürr

NADPH oxidases transport electrons from cytosolic NADPH through biological membranes to generate reactive oxygen species. NADPH oxidase 4, broadly expressed in humans, is an interesting pharmacological target, since its activity is deregulated in several diseases, including pulmonary fibrosis, diabetic nephropathy, and cardiac hypertrophy. Whereas several candidate NADPH oxidase 4 inhibitors we...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994
R Spessert E Layes

NADPH-diaphorase (NADPH-d) is commonly used as a histochemical marker for the neuronal form of the enzyme nitric oxide synthase (NOS). A recent biochemical study showed that in broken-cell preparations NADPH-d activity did not fully represent NOS and that NOS-unrelated NADPH-d activity was suppressed during fixation. Because it is unknown whether fixation also affects NOS-associated NADPH-d act...

2001
Shigenobu Umeki

The kinetics of sodium dodecyl sulfate-induced activation of respiratory burst oxidase (NADPH oxidase) in a fully soluble cell-free system from resting (control) or phorbol myristate acetate (PMA)-stimulated human neutrophils were investigated. In a cell-free system containing solubilized membranes and cytosol fractions (cytosol) derived from control neutrophils (control cell-free system), the ...

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