British Association of Dermatologists’ guidelines for the management of bullous pemphigoid 2012 V.A. Venning, K. Taghipour, M.F. Mohd Mustapa, A.S. Highet and G. Kirtschig Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, U.K. Department of Dermatology, Whittington Hospital, Magdala Avenue, London N19 5NF, U.K. British Association of Dermatologists, Willan Hou...

Ultraviolet radiation is the main cause of DNA damage to melanocytes and development of melanoma, one of the most lethal human cancers, which leads to metastasis due to uncontrolled cell proliferation and migration. These phenotypes are mediated by RhoA, a GTPase overexpressed or overactivated in highly aggressive metastatic tumors that plays regulatory roles in cell cycle progression and cytos...

Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small GTPase proteins of the Rho family. To investigate the role of Rho A in podocyte biology, we created transgenic mice expressing doxycycline-inducible constitutively active (V14 Rho) or dominant-negative Rho A (N19 Rho) in podocytes. Specific ...

A rapid screening (hydroponic) and field testing programme There is increasing interest in improving the nitrogen (N) use efficiency of cultivated crops, due to the high cost of synthetic N fertiliser. Since existing differences in N use efficiency between sugarcane varieties could be exploited to improve N fertilisation, a hydroponic pot experiment was conducted to test the performance of seve...

Radiotherapy with γ-radiation is widely used in cancer treatment to induce DNA damage reducing cell proliferation and to kill tumor cells. Although RhoA GTPase overexpression/hyperactivation is observed in many malignancies, the effect of RhoA activity modulation on cancer radiosensitivity has not been previously investigated. Here, we generated stable HeLa cell clones expressing either the dom...

Correspondence to: Mr Robert Din, 11 Southcote Road, Tufnell Park, London N19 5BJ. A 41 year old man presented after a road traffic accident. He was a motorcyclist travelling at 30 mph and was thrown from his motorcycle. Physical examination was unremarkable apart from a painful deformed right lower limb, with neurovascular structures intact. Radiography revealed a midshaft oblique fracture of ...

Somatosensory evoked potentials (SEPs) to median nerve stimulation were recorded in controls and in patients with focal lesions in dorsolateral prefrontal cortex (PFCx). Unilateral PFCx lesions increased the amplitude of the P26 component generated in postcentral areas 1 and 2. The amplitudes of the N28, P45 and N67 SEP components recorded over post-rolandic and frontal electrodes were also enh...

South African sugarcane varieties N23 and N25 were compared against industry standards NCo376 and N19 on soils with low yield potential in four replicated, irrigated trials comprising a total of 17 crops, harvested either early, mid or late in the milling season. Chemical ripeners ethephon (2-chloroethanephosphonic acid) and Fusilade Super (fluazifop-p-butyl) were applied either alone or as a c...

The effects on sucrose yield of varying the time interval between Ethrel and Fusilade Super applications in a combination treatment were tested on variety NC0376. Results suggested that Ethrel applied 12 weeks, and Fusilade Super applied eight weeks before harvesting were the most beneficial. Other varieties which responded to a combination treatment were N19, N12 and N22. Varieties N14, N19, N...