It is becoming well recognized that metabolic perturbations are inherent hallmarks of tumorigenesis [1,2]. Metabolites represent the functional products of cellular processes, which are highly responsive to both pathological and environmental stimuli. As such, metabolites are the closest representation of an individual’s current physiological state. Therefore, exploration of metabolic alteratio...

A method for the calculation of the hyper–Wiener index (WW ) of a benzenoid system B is described, based on its elementary cuts. A pair of elementary cuts partitions the vertices of B into four fragments, possessing nrs , r, s = 1, 2 vertices. WW is equal to the sum of terms of the form n11 n22 + n12 n21 . The applicability of the method is illustrated by deducing a general expression for WW of...

Trabectedin and its N12-demethylated analogue ET729 bind covalently to the central guanine of selected DNA triplets. Although both drugs equally target several sites, including AGA, we show that covalent modification of CGA is only achieved by ET729. By means of molecular dynamics simulations of the precovalent complexes, we explain in atomic detail how such a simple structural modification bri...

The pathogenesis of acute myeloid leukemia (AML) involves the cooperation of mutations promoting proliferation/survival and those impairing differentiation. The RAS pathway has been implicated as a key component of the proliferative drive in AML. We have screened AML patients, predominantly younger than 60 years and treated within 2 clinical trials, for NRAS (n = 1106), KRAS (n = 739), and HRAS...

10-Year survival (10YS) after radical surgery for gastric cancer (GC) patients (GCP) (T1-4N0-2M0) was analyzed. We analyzed data of 796 consecutive GCP (age=57.1±9.4 years; tumor size=5.4±3.1 cm) radically operated (R0) and monitored in 1975-2021 (m=556, f=240; distal gastrectomies-G=461, proximal G=165, total G=170, D2 lymph node dissection=551; combined G with resection 1-7 adjacent organs (p...

As a resource for vertebrate phylogenetics, we developed 75 new protein-coding genes using a combination of expressed sequence tags (ESTs) available in Genbank, and targeted amplification of complementary DNA (cDNA). In addition, we performed three additional analyses in order to assess the utility of our approach. First, we profiled the phylogenetic informativeness of these new markers using t...

The yield responses of sugarcane to lime and gypsum at two sites in the KwaZulu-Natal Midlands of South Africa are presented and discussed. At Dalton, on a Magwa form soil with an initial aluminium saturation index (ASI) of >80%, over a plant and four ratoon crops variety N12 gave no significant response to dolomitic lime. By contrast, variety N16 gave consistent yield responses to lime at rate...