The carcinogenicity of five derivatives of nitrosodiethylamine was compared with that of the parent compound by p.o. administration to rats. All were less potent than was nitrosodiethylamine. When nitrosobis(2-methoxyethyl)amine and nitrosobis(2-ethoxyethyl)amine were ad ministered at equimolar doses in drinking water, there was a high incidence of liver tumors, but the animals died later than ...

We tested whether a concentration of unleaded gasoline (UG) vapor that was selectively hepatocarcinogenic in female mice in a chronic bioassay is antiestrogenic and whether liver tumor promotion by UG is secondary to antiestrogenicity. Twelve-day-old female C57BL/6 x C3H F1 mice (hereafter called B6C3F1) received i.p. injections of N-nitrosodiethylamine (5 mg/kg) or vehicle. Beginning at 5-7 we...

To investigate the hypothesis that tumor promotion by chlorinated aromatic hydrocarbons involves Ah receptor occupation and subsequent induction of cytochromes P-450 1a-1, effects of Aroclor 1254 or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were examined in N-nitrosodiethylamine-initiated mice with different Ah receptor phenotype. Levels of cytochromes P-450 1a and 2b were measured by enzyme a...

An analytical method for the determination of N-nitrosodimethylamine (N-NDMA) in environmental aqueous samples has been developed using isotope dilution gas chromatography/mass spectrometry in the selected ion monitoring mode (GC/MS-SIM). After deuterated N-nitrosodimethylamine (d6-N-NDMA) as surrogate standard was added to the samples, the analytes were extracted with methylene chloride, dried...