نتایج جستجو برای: myometrium

تعداد نتایج: 2097  

Journal: :The Journal of clinical investigation 1999
Y L Dong L Fang S Kondapaka P R Gangula S J Wimalawansa C Yallampalli

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and relaxes smooth muscle of a variety of tissues, but the effects of CGRP on human myometrial contractions and the changes in CGRP receptors (CGRP-Rs) in human myometrium have not been described. We report that CGRP induced dose-dependent relaxation in spontaneously contracting myometrium from pregnant women. This relaxation effect...

2011
Satyanarayana Rao

Objectives: To study the histomorphological features of variants of leiomyomas of myometrium in our institution from hysterectomy and myomectomy specimens. Methods: In this prospective study, 1,845 hysterectomy and myomectomy specimens collected over a period of two years were studied. A detailed gross and microscopic examination of tumors of myometrium were made after fixing and staining the s...

Journal: :Molecular human reproduction 2008
Hiromi Asada Yoshiaki Yamagata Toshiaki Taketani Aki Matsuoka Hiroshi Tamura Naoko Hattori Jun Ohgane Naka Hattori Kunio Shiota Norihiro Sugino

Uterine leiomyomas are the most common uterine tumors in women. Estrogen receptor-alpha (ER-alpha) is more highly expressed in uterine leiomyomas than in normal myometrium, suggesting a link between uterine leiomyomas and ER-alpha expression. DNA methylation is an epigenetic mechanism of gene regulation and plays important roles in normal embryonic development and in disease progression includi...

Journal: :Reproductive Biology and Endocrinology : RB&E 2009
Binhai Cong Lanmei Zhang Lu Gao Xin Ni

BACKGROUND Corticotropin-releasing hormone (CRH) and CRH-related peptide are shown to modulate uterine contractility through two CRH receptor subtype, CRH-R1 and CRH-R2 during pregnancy. Through different signaling pathways, CRH-R1 maintains myometrial quiescence whereas CRH-R2 promotes smooth muscle contractility. We hypothesized that the expression of CRH receptors in myometrium might be chan...

Journal: :Molecular human reproduction 2006
A Hever R B Roth P A Hevezi J Lee D Willhite E C White E M Marin R Herrera H M Acosta A J Acosta A Zlotnik

Adenomyosis is a common gynaecological disorder characterized by the abnormal growth of endometrium into the myometrium and myometrial hypertrophy/hyperplasia. Uterine fibroids are benign neoplasms of the myometrium, and they represent a diagnostic pitfall for adenomyosis. In this study, we have used the genome-wide Affymetrix U133 Plus 2.0 microarray platform to compare the gene expression pat...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2000
S Hague L Zhang M K Oehler S Manek I Z MacKenzie R Bicknell M C Rees

Uterine leiomyomas are the most prevalent benign tumor type in women of reproductive age and are one of the most common indications for hysterectomy. The expression of five angiogenic factors, adrenomedullin (ADM), vascular endothelial growth factor (VEGF), acidic fibroblast growth factor, basic fibroblast growth factor, and platelet-derived endothelial cell growth factor/thymidine phosphorylas...

2016
Annu Makker Madhu Mati Goel Abbas Ali Mahdi Vikram Bhatia Vinita Das Anjoo Agarwal Amita Pandey

BACKGROUND & OBJECTIVES Despite their high occurrence and associated significant level of morbidity manifesting as spectrum of clinical symptoms, the pathogenesis of uterine leiomyomas (ULs) remains unclear. We investigated expression profile of tumour suppressor genes PTEN (phosphatase and tensin homolog deleted on chromosome ten) and LKB1 (liver kinase B1), and key signaling components of P13...

2015
Agnieszka Skowronska Patrycja Mlotkowska Soren Nielsen Mariusz T. Skowronski

BACKGROUND Recently, we demonstrated in vitro that AQP1 and AQP5 in the porcine uterus are regulated by steroid hormones (P4, E2), arachidonic acid (AA), forskolin (FSK) and cAMP during the estrous cycle. However, the potential of the porcine separated uterine tissues, the endometrium and myometrium, to express these AQPs remains unknown. Thus, in this study, the responses of AQP1 and AQP5 to P...

Journal: :iranian journal of pharmaceutical sciences 0
fatemeh fathiazad depatment of pharmacognosy, , faculty of pharmacy, tabriz, iran yadollah azarmi depatment of pharmacology, faculty of pharmacy, tabrizuniversity of medical sciences, tabriz, iran laleh khodaie depatment of pharmacognosy, faculty of pharmacy, tabriz, iran

the effects of hydroalcoholic extract of peganum harmala seeds (eps) on spontaneous rhythmic contractions of isolated rat uterine was investigated in this study. eps was tested on the isolated uterus and endometrium free (i.e. stripped myometrium) preparations. eps was found to exhibit significant spontaneous contractions of the uterus and stripped myometrium relative to the solvent control. af...

2017
Frederic Buxant Sven Saussez Jean Christophe Noël

Uterine leiomyoma is the most common benign smooth muscle tumour that originates from the myometrium. Ovarian sex steroids are responsible for the growth of such tumours, though estrogen and progesterone are not the only modulators involved in the tumourigenesis and growth of leiomyomata. The activation of glucocorticoid receptor (GR) can induce the expression and activity of estrogen sulfotran...

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