Sudden cardiac deaths due to giant cell myocarditis (GCM) are uncommon. Giant cell myocarditis is an inflammatory myocardial disease. It is characterized by inflammation of the heart muscle (myocardium), a condition referred to as myocarditis. Inflammation is caused by widespread infiltration of giant cells associated with other inflammatory cells and cardiac muscles cell destruction. Giant cel...

Myocarditis can lead to acute heart failure, cardiogenic shock, or sudden death and later, dilated cardiomyopathy (DCM) with chronic heart failure. We report the cases of two DCM induced by acute and past myocarditis in the same family and expressed by its two main complications within few weeks: an hemodynamic presentation as a fulminant myocarditis rapidly leading to cardiac tranplantation an...

OBJECTIVES Giant cell myocarditis is a rare and often fatal disorder. According to the American Heart Association, the American College of Cardiology Foundation, and the European Society of Cardiology scientific statements, an endomyocardial biopsy should be done to exclude giant cell myocarditis in unexplained new-onset heart failure of 2 weeks to 3 months duration associated with dilated left...

NViral inifectionis may ox7erload the heart by alterinig pulmonary or systemic vascular resistance, mav iniduce conigeniital malformations, or may invade the mature heart muscle and provoke acute anid possibly chlronic myocarditis. The nature of the associationi of myocarditis vith kniowvn viral infections anid the pathophysiologic effects of myocardial involvenmeit are analyzed. Altlhough vira...

Myocarditis is an uncommon condition encompassing a spectrum from asymptomatic cases to fulminant heart failure. Acute fulminant myocarditis is characterised by severe haemodynamic compromise often necessitating circulatory support. The diagnosis and management of myocarditis remains challenging with uncertainty surrounding the role of immunosuppression therapy. We describe a case of biopsy-pro...

Inflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in children and young adults. DCMi develops in up to 30% of myocarditis patients, but the mechanisms involved in disease progression are poorly understood. Patients with eosinophilia frequently develop cardiomyopathies. In this study, we used the experimental autoimmune myocarditis (EAM) model to determine the role of ...

Introduction. Myocarditis is known to occur in 5–25 % of COVID-19 cases and associated with increased mortality. According studies, even a mild course high risk cardiovascular disease. Possible mechanisms myocarditis are combination direct viral damage the myocardium human immune response affected myocardium. Along acute manifestations, as fulminant myocarditis, may also be an long-term complic...

RATIONALE In recent work, we have demonstrated a crucial role of mast cells in the development of viral myocarditis. Viral infection could lead to increased synthesis of free immunoglobulin light chains (FLC) and our earlier work showed that FLC can trigger mast cell activation. OBJECTIVE We studied the possible involvement of FLC in the pathogenesis of viral myocarditis, and therapeutic effe...

The clinical and pathologic features of 18 consecutive patients with peripartum cardiomyopathy at The Johns Hopkins Hospital were examined in an attempt to define the incidence of myocarditis and to determine its response to immunosuppressive agents. In addition to routine studies, patients were evaluated with echocardiography, nuclear ventriculography, right heart catheterization, and myocardi...

BACKGROUND Previous studies suggest that children with myocarditis who receive heart transplantation (HT) may be at higher risk of post-transplant mortality compared with children who are transplanted for idiopathic dilated cardiomyopathy. We hypothesized that these differences are because of more severe heart failure at HT in children with myocarditis. METHODS AND RESULTS We identified 221 c...