نتایج جستجو برای: myocardial metabolic uptake

تعداد نتایج: 490598  

Journal: :Circulation 2009
Aslan T Turer Robert D Stevens James R Bain Michael J Muehlbauer Johannes van der Westhuizen Joseph P Mathew Debra A Schwinn Donald D Glower Christopher B Newgard Mihai V Podgoreanu

BACKGROUND Human myocardial metabolism has been incompletely characterized in the setting of surgical cardioplegic arrest and ischemia/reperfusion. Furthermore, the effect of preexisting ventricular state on ischemia-induced metabolic derangements has not been established. METHODS AND RESULTS We applied a mass spectrometry-based platform to profile 63 intermediary metabolites in serial paired...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012
Ashima Lyall Julia Capobianco H William Strauss Mithat Gonen Heiko Schöder

We report the effects of treadmill exercise on (18)F-FDG uptake in skeletal muscles and image quality of torso PET and compare stress myocardial perfusion imaging patterns with myocardial (18)F-FDG uptake. There were 3 groups of patients: 48 patients underwent PET within 8 h after a treadmill test (Ex 8), 45 patients within 48 h after a treadmill test (Ex 48), and 34 patients without prior exer...

  Bilateral diffuse intense breast uptake was noted in a 40 year old female who was evaluated with Tc-99m sestamibi (MIBI) myocardial perfusion scan for possible ischemia. She was breast feeding her 1.5 year old child. The intense uptake in the breasts was superimposed on the apical and anteroapical regions of the myocardium and caused interpretation problem. We recom...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996
K Kubota R Kubota S Yamada M Tada T Takahashi R Iwata

UNLABELLED Myocardial [18F] fluorodeoxyglucose (FDG) uptake depends on several metabolic variables in vivo. The effect of different levels of experimentally induced hyperglycemia on myocardial FDG uptake was examined. METHODS FDG uptake was studied in young Donryu rats 1 hr after intravenous injection under various pretreatments that increased serum glucose levels. Serum samples were analyzed...

Journal: :Circulation 2001
T R Wallhaus M Taylor T R DeGrado D C Russell P Stanko R J Nickles C K Stone

BACKGROUND Use of beta-adrenoreceptor blockade in the treatment of heart failure has been associated with a reduction in myocardial oxygen consumption and an improvement in myocardial energy efficiency. One potential mechanism for this beneficial effect is a shift in myocardial substrate use from increased free fatty acid (FFA) oxidation to increased glucose oxidation. METHODS AND RESULTS We ...

2014
Miyako Morooka Masao Moroi Kimiichi Uno Kimiteru Ito Jin Wu Takashi Nakagawa Kazuo Kubota Ryogo Minamimoto Yoko Miyata Momoko Okasaki Osamu Okazaki Yoshihito Yamada Tetsuo Yamaguchi Michiaki Hiroe

BACKGROUND F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibiting physiological myocardial 18F-FDG uptake have been proposed, no standard ...

2016
ELDAD RECHAVIA SUDHIR S. KUSHWAHA LUIS I. ARAUJO

Objectives. We sought to assess the relation between glucose metabolism, myocardial perfusion and cardiac work after orthotopic heart transplantation. Background. The metabolic profile of the transplanted cardiac muscle is affected by the lack of sympathetic innervation, impaired inotropic function, chronic vasculopathy, allograft rejection and immunosuppressive therapy. In relation to myocardi...

2017
Cher-Rin Chong Kieran Clarke Eylem Levelt

Diabetes is a risk factor for heart failure and cardiovascular mortality with specific changes to myocardial metabolism, energetics, structure, and function. The gradual impairment of insulin production and signalling in diabetes is associated with elevated plasma fatty acids and increased myocardial free fatty acid uptake and activation of the transcription factor PPARα. The increased free fat...

Journal: :The Journal of clinical investigation 2002
Brian N Finck John J Lehman Teresa C Leone Michael J Welch Michael J Bennett Attila Kovacs Xianlin Han Richard W Gross Ray Kozak Gary D Lopaschuk Daniel P Kelly

Recent evidence has defined an important role for PPARalpha in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARalpha in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice with cardiac-restricted overexpression of PPARalpha (MHC-PPAR) were produced and characterized. The expression of PPARalpha target genes involved ...

2011
Weike Bao Karpagam Aravindhan Hasan Alsaid Thimmaiah Chendrimada Matthew Szapacs David R. Citerone Mark R. Harpel Robert N. Willette John J. Lepore Beat M. Jucker

BACKGROUND The cardioprotective effects of glucagon-like peptide-1 (GLP-1) and analogs have been previously reported. We tested the hypothesis that albiglutide, a novel long half-life analog of GLP-1, may protect the heart against I/R injury by increasing carbohydrate utilization and improving cardiac energetic efficiency. METHODS/PRINCIPAL FINDINGS Sprague-Dawley rats were treated with albig...

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