................................................................................................................... 1 POPULÄRVETENSKAPLIG SAMMANFATTNING .................................................. 1 LIST OF PAPERS ........................................................................................................... 3 ABBREVIATIONS .......................................................

According to the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, myelodysplastic/myeloproliferative neoplasms are clonal myeloid neoplasms that have some clinical, laboratory, or morphologic findings that support a diagnosis of myelodysplastic syndrome, and other findings that are more consistent with myeloproliferative neoplasms. These disorders ...

Hydroxycarbamide is a nonalkylating antiproliferative and antiviral agent that has been used for over 40 years to treat a variety of neoplastic and non-neoplastic conditions. Hydroxycarbamide is readily absorbed and widely distributed throughout the body. It acts primarily to inhibit DNA synthesis, which underpins its use in solid tumors, viral infections and chronic myeloproliferative disorder...

BACKGROUND The clonal origin of myeloproliferative disorders has been clearly demonstrated and it is known that reactive thrombocytosis occurs as a non specific response to various inflammatory or neoplastic conditions. Only a few papers have discussed the topic of myeloproliferative diseases in blood donors. MATERIALS AND METHODS We report 8 cases of myeloproliferative diseases (3 polycythem...

By D. L. DUNGwORTH, NI. GOLDMAN, J. W. SWITZER AND D. H. MCKELVIE T HE TERM “MYELOPROLIFERATIVE DISORDER” was introduced by 2 to embrace a complex array of diseases characterized by irreversible proliferation of one to several of the bone marrow cell lines, and includes such conditions as granulocytic leukemia, myelofibrosis with myeloid metaplasia, polycythemia vera and erythremic myelosis. Th...

Bone marrow biopsies of 850 patients with chronic myeloproliferative disorders were taken at initial diagnosis; and 169 sequential biopsies over periods of one to 188 months. Three micron sections of all biopsies were evaluated semiquantitatively with reference to the proliferating cell lines, anomalies of megakaryocytes, and fibrosis or osteosclerosis. Correlations between initial histological...