results of the 89 subjects, 53 were male and 36 females, aged 14 to 82 years. there was no significant difference between ebv seroprevalence in the patients with lymphoma and multiple myeloma, and the healthy subjects. conclusions the results of the current study indicated no relationship between latent ebv infection and lymphoma or multiple myeloma. however, further studies with larger sample ...

multiple myeloma (mm) is characterized by progressive proliferation of malignant plasma cells, usually initiating in the bone marrow. mm can affect any organ; a total of 7 - 18% of patients with mm demonstrate extramedullary involvement at diagnosis. non-secretory multiple myeloma (nsmm) is a rare variant that accounts for 1 - 5% of all cases of multiple myeloma. the disease is characterized by...

introduction: multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia, and hypercalcemia. the hyperviscosity syndrome is rare. cryoglobulins are immunoglubulins that precipitate in the cold temperature less than 37˚c. monoclonal cryoglobulins are associated with...

multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. it is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. the prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. the tre...

Involvement of the peripheral nervous system is one of the complications of multiple myeloma with a varying incidence of clinical and subclinical neuropathy in different studies. As most of the patients with multiple myeloma suffer from generalized systemic symptoms such as malaise, bone and low back pain, the clinical clues to the diagnosis of the neuropathy in its initial stages could be ...

objective: receptor activator of nuclear factor-kappa b ligand (rankl) appears to be an osteoclast-activating factor, bearing an important role in the pathogenesis of multiple myeloma. some studies demonstrated that u-266 myeloma cell line and primary myeloma cells expressed rank and rankl. it had been reported that the expression of myeloid and monocytoid markers was increased by co-culturing ...

This Policy Review presents the International Myeloma Working Group's clinical practice recommendations for treatment of relapsed and refractory multiple myeloma. Based on results phase 2 3 trials, these are proposed patients with disease who have received one previous line therapy, myeloma two or more lines therapy. These integrate issue drug access in both low-income middle-income countries h...