recent studies have indicated that 1, 4-dihydropyridine-3, 5-dicarboxamidederivativesshow significant anti-tubercular activity. in this research, new derivatives of 1, 4-dihydropyridine were designed and synthesized using hantzsch condensation in which dicyclohexyl and different dicyclohexylcarbamoylwere substituted at c-3 and c-5 positions of the dhp ring.in addition, 4 (5)-chloro-2-methyl-5 (...

results slow and fast-growing groups of the mycobacterium strains were clearly differentiated based on the constructed tree of 56 common mycobacterium isolates. each species with a unique title in the tree was identified; in total, 13 nods with a bootstrap value of over 50% were supported. among the slow-growing group was mycobacterium kansasii, with m. tuberculosis in a cluster with a bootstra...

0

introduction an unusual incidence of tuberculosis in different parts of the body is called tuberculomas. the rate of brain tuberculosis is rare. case presentation the following case of tuberculamas of the brain, presented by enhancing rings of meninges, is reported because of its rarity. it was a case of brain tuberculomas in a 15-year-old girl with primary symptoms of headache and general weak...

to investigate the prevalence of mycobacterium paratuberculosis (m. avium subsp. paratuberculosis)infection among cattle slaughtered in ahvaz abattoir, samples were taken from 250 cattle. before slaughter,sex and age were assessed. thereafter, samples were taken from ileocecal valve, rectum mucosa, ileocecallymph node and stool. all smears which taken from these samples were stained by ziehl-ne...

background pe5 is a member of the pe protein family whose precise function is yet to be understood. there are about 100 members of the pe family proteins in mycobacterium tuberculosis. these glycine- and alanine-rich proteins consist of proline-glutamate motifs at their n-termini and may be implicated in pathogenesis of the bacilli. objectives we aimed to clone and over-express the rv0285 codin...

abstract background and objective: a high level of homogeneity observed within all bacteria in the mycobacterium tuberculosis complex makes a property that seriously challenges traditional biochemical-based identification methods of these pathogens in the laboratory. the work presented here was conducted to characterize mycobacterium tuberculosis complex isolates in golestan, northern iran. mat...

In summary, in order to control tuberculosis, we require a rapid diagnosis of TB patients, who act as the source of disease; and if remain untreated, these patients can spread the disease throughout the population. Therefore, we need to introduce the new approach for quick and accurate identification of Mycobacterium tuberculosis, and CYP141 gene is a new approach for rapid and accura...

The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered vaccines this population. We carried out a Phase I trial evaluate safety and delivered UK LTBI (NCT02532036). Two volunteers were recruited, well-tolerated no c...