Background Endometriosis is a common gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. This disease affects approximately 10% of women in reproductive age and is associated with pelvic pain, dysmenorrhea and infertility. The theory of involvement of stem cells is a considered new hypothesis in etiology of endometriosis.The aim of this study wa...

According to the International Consensus Classification of Lymphomas (Blood 2022: 140: 1229–53), a new provisional entity high grade B cell lymphoma with MYC and BCL 6 rearrangements (HGBCL-DH-BCL6) was introduced. HGBCL-DH-BCL6 occurred very rare, in less than 10% patients HGBCL rearrangements. Here we assessed clinicopathological features treatment outcomes HGBCL-DH-BCL6. We retrospectively c...

Introduction Background: Considering the poorly understood mechanism of lysine demethylase 1A (KDM1A) in osteosarcoma (OS), we here commence our investigation to fill blank. Material and methods Methods: Following transfection as appropriate, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) flow cytometry assays were used determine viability apoptosis OS cells MG-63, which ge...

Uncontrolled proliferation and apoptosis evasion are two hallmarks of acute myeloid leukemia (AML), but the molecular mechanisms remain poorly understood. In this study, it is demonstrated that double over-expresser oncoprotein c-Myc anti-apoptotic protein Bcl-2 a critical “genetic overdrive” in AML associated with poor genetic alterations. Double-knockdown c-Myc/ synergistically kills cells vi...

Background: The proto-oncogene Myc is known to play critical roles in tumorigenesis and therapeutic resistance, being dysregulated up 70% of all human cancers. Heterodimerization with its binding partner Max required for oncogenic transformation, yet the development small molecule inhibitors has been hampered due lack suitable pockets. inhibitory peptides derived from first helix (H1) bHLH-LZ r...

Objective(s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.Materials and Methods: Diabetes was i...

AIM. The aim of the study was to analyze Avra's effector in inducing cancer stem cells into colon through increased radical oxygen species (ROS), PTEN expression and c-myC as markers tumorigenesis mice model colorectal infected with S. typhimurium.
 METHODS. used balb c induced once a week by 10 mg / mL day AOM for 1-week 12-week treatment period. Isolation typhimurium specific protein had...

Abstract MYC family proteins are primary drivers of oncogenic processes in a variety cancer histologies. N-myc overexpression and amplification induce aggressive pediatric cancers, the most common which solid extracranial tumors children (neuroblastoma, NB) malignant CNS (medulloblastoma, MB). Due to addiction observed these tumor types, is considered an attractive therapeutic target. However, ...

Abstract BACKGROUND The expression of MYC in tumor cells regulates the microenvironment through innate and adaptive immune effector regulatory cytokines. has also been shown to regulate checkpoint gene products CD47 programmed death-ligand 1 (PD-L1). While PD-L1 inhibits response, on binds SIRPa macrophages acts as a “Don’t eat me” signal. We have previously that blocking CD47-SIRPa pathway sig...