scid disorder is major failure of the immune system, usually genetic. the aim of this study was on mutations detection of rag1, rag2, and il7rg genes in scid cases. mutation detection was performed by pcr sequencing. our results  indicated  that 13  mutations  were found  through  cases which  include 4 mutations in il7r gene (t661i, i138v, t56a, c57w), 7 mutations in rag1 (w896x, w204r, m324v,...

introduction: the myeloproliferative neoplasms (mpns) are a heterogeneous group of diseases characterized by excessive production of blood cells by  hematopoietic precursors. typically, they include polycythemia vera (pv), essential thrombocythemia (et), idiopathic myelofibrosis(imf), and chronic myeloid leukemia (cml). philadelphia chromosome is the final diagnostic test for cml. recently, jak...

Since the original description of Helicobacter plvori by Warren and Marshall in 1983 there has been a virtual explosion in interest in this organism. It is now causally linked to chronic gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue lymphoma and possibly gastric cancer. It has proved to be the single most important advance in modern gastroenterology. This book is a ...

background :according to numerous studies, fms-like tyrosine kinase 3, internal tandem duplication, and the d835 mutation are associated with a poor prognostic clinical outcome in acute myeloid leukemia patients. detection of the fms-like tyrosine kinase 3 mutation in patients who present with normal karyotype acute myeloid leukemia helps in both the understanding of the disease and the treatme...

addressed the feasibility of obtaining sensitive, accurate, and reproducible mutation detection results in synthetic templates, cell lines, and FFPE tissue samples using TaqMan Mutation Detection Assays. Analytical performance assessed with synthetic templates and genomic DNA (gDNA) extracted from cell lines or model FFPE cell lines indicates that TaqMan Mutation Detection Assays have a minimum...

Two mechanisms have recently been proposed that can significantly speed up finding distant improving solutions via mutation, namely using a random mutation rate drawn from heavy-tailed distribution (“fast mutation”, Doerr et al. (2017) [2]) and increasing the strength based on stagnation detection mechanism (Rajabi Witt (2020) [3]). Whereas latter obtain asymptotically best probability of singl...