Experimental studies on the complex process of mutagenesis are conducted in the belief that they will increase our understanding of the effects of environmental agents on human populations. Cultured mammalian cells offer distinct advantages over other biological systems for studying this problem. Mutagenesis in cultured mammalian cells is unquestionably more relevant to man than are bacterial, ...

We have used high-pressure liquid chromatography and the Salmonella/microsome mutagenicity test to look for mutagenic impurities in 11 carcinogens and noncarcinogens. Because of the million-fold range in mutagenic potency observed in the Salmonella test, even trace amounts of potent mutagenic impurities in a nonmutagenic compound could be detected. The mutagenicity of 7-hydroxy-2-acetylaminoflu...

The conclusions stated after evaluation of 49 test results are presented in Table 1 for the in vivo mutagenicity and in Table 2 for in vitro mutagenicity. To evaluate the mutagenicity of the product, the criteria in point 4.2.2 of the Annex VI to the Directive 67/548/EEC are used. The tests using intra-peritoneal administration are not taken into account to determine the mutagenicity of hydroqu...

BACKGROUND Semen armeniacae amarum (SAA) is a Chinese traditional medicine and has long been used to control acute lower respiratory tract infection and asthma, as a result of its expectorant and antiasthmatic activities. However, its mutagenicity in vitro and in vivo has not yet been reported. The Ames test for mutagenicity is used worldwide. The histidine contained in biological samples can i...

Three workshops have been organised previously nder the auspices of the International Workshops on enotoxicity Testing (IWGT). Recognising the success f these earlier workshops, the International Associaion of Environmental Mutagen Societies (IAEMS) foralised these workshops in 2002 under the IAEMS mbrella and agreed that they would be held on a contining basis in conjunction with the Internati...

Metaphors are powerful tools for sensemaking, sensegiving and theory development, but they are often concealed in academic writing. This paper uncovers two metaphors underlying entrepreneurship discourse and research – elixir and mutagen. The elixir metaphor is uncovered by examining critiques of entrepreneurship research and serves as a compact description of problematic aspects entrepreneursh...

Hair dye ingredients frequently produce positive results in short-term in vitro genotoxicity tests, although results from in vivo assays are typically negative, especially for ingredients in use today. The use of hair dyes is quite widespread resulting in the exposure both for persons working in hairdressing salons and for individuals who have their hair dyed. This provides the opportunity to a...

Saccharomyces cerevisiae has been widely used in mutagenicity tests due to the presence of a cytochrome P-450 system, capable of metabolizing promutagens to active mutagens. There are a large number of S. cerevisiae strains with varying abilities to produce cytochrome P-450. However, strain selection and ideal cultivation conditions are not well defined. We compared cytochrome P-450 levels in f...