The bacterial mutagenicity of a set of 1993 urban particulate air pollution samples is examined using the Salmonella typhimurium TM677 forward mutation assay. Amibent fine particulate samples were collected for 24 hr every sixth day throughout 1993 at four urban sites, including Long Beach, central Los Angeles, Azusa, and Rubidoux, California, and at an upwind background site on San Nicolas Isl...

2.3.3. Carcinogenicity of N-Nitrosamines 1781 2.4. Quinolines 1781 2.5. Triazenes 1782 2.6. Polycyclic Aromatic Hydrocarbons 1783 2.6.1. QSARs for the Carcinogenicity of PAHs 1783 2.6.2. QSARs for the Genotoxicity of PAHs 1784 2.7. Halogenated Aliphatics 1784 2.8. Direct-Acting Compounds 1785 2.8.1. Mutagenicity of Platinum Amines 1785 2.8.2. Mutagenicity of Lactones 1785 2.8.3. Mutagenicity of...

4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with and without S9 activation was established with Salmonella strains TA98 and TA100 and that of the stilbenes with the same strains plus TA98/1,8-DNP6. The in vivo genotoxicity assay with both series of ...

OBJECTIVES Several studies have suggested that genotoxic risks might still be present in the contemporary rubber manufacturing industry. Previously, we observed elevated levels of urinary mutagenicity and bladder DNA adducts in rubber workers. Presently, we investigated whether DNA adducts in peripheral blood mononuclear cells (PBMC) and/or urothelial cells may be caused by polycyclic aromatic ...

waterpipe smoking has become a global youth trend especially in the middle east countries and iran . the aim of this study was to determine the mutagenic effects of three most popular flavored tobaccos by four different salmonella typhimurium strains and compare the possible mutagenic effects of the test samples. ames mutagenicity assessment was conducted according to the oecd guideline using t...

The cellular and molecular mechanisms of how asbestos fibers induce cancers and other diseases are not well understood. Both serpentine and amphibole asbestos fibers have been shown to induce oxidative stress, inflammatory responses, cellular toxicity and tissue injuries, genetic changes, and epigenetic alterations in target cells in vitro and tissues in vivo. Most of these mechanisms are belie...

The mutagenicity of ten flavonoids was assayed by the Ames test, in Salmonella typhimurium strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles. The compounds assessed were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In the Ames assay, quer...

Malondialdehyde, a product of lipid peroxidation and prostaglandin biosynthesis, is mutagenic in Salmonella. To determine the molecular requirements for its mutagenicity, we tested a series of beta-substituted acroleins in Salmonella typhimurium hisD3052 . Mutagenicity is dependent on the steric bulk of the substituent (revertants/mumol) at the beta position: beta- methoxyacrolein , 220; beta- ...