D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.

AIM To investigate the anti-proliferative and apoptotic effects of Chaga mushroom (Inonotus obliquus) water extract on human hepatoma cell lines, HepG2 and Hep3B cells. METHODS The cytotoxicity of Chaga extract was screened by 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Morphological observation, flow cytometry analysis, Western blot were employed to elucidate t...

Ganoderma lucidum is one of the most widely studied mushroom species, particularly in what concerns its medicinal properties. Previous studies (including those from some of us) have shown some evidence that the methanolic extract of G. lucidum affects cellular autophagy. However, it was not known if it induces autophagy or decreases the autophagic flux. The treatment of a gastric adenocarcinoma...

Introduction: Mushrooms are a manifestation of a common saying, ‘Medicines and foods have a common origin’, in constituting both a nutritionally functional food and a source of physiologically beneficial medicine. The present studies were undertaken to investigate the effects of dried mushroom and mushroom extract on the lipid profile, lipid peroxidation and liver function of aging Swiss albino...

AIMS The main objective of this study was to evaluate the capacity of wild mushroom extracts to potentiate the action of standard antibiotics, through synergisms that allow a decrease in their therapeutic doses and ultimately contribute to the reduction of resistances. METHODS AND RESULTS Wild mushroom extracts were applied to different multiresistant micro-organisms (Escherichia coli, extend...

White button mushrooms (Agaricus bisporous) are a potential breast cancer chemopreventive agent, as they suppress aromatase activity and estrogen biosynthesis. Therefore, we evaluated the activity of mushroom extracts in the estrogen receptor–positive/aromatase-positive MCF-7aro cell line in vitro and in vivo . Mushroom extract decreased testosterone-induced cell proliferation in MCF-7aro cells...

White button mushrooms (Agaricus bisporous) are a potential breast cancer chemopreventive agent, as they suppress aromatase activity and estrogen biosynthesis. Therefore, we evaluated the activity of mushroom extracts in the estrogen receptor-positive/aromatase-positive MCF-7aro cell line in vitro and in vivo. Mushroom extract decreased testosterone-induced cell proliferation in MCF-7aro cells ...

Background: Drugs dedicated to alleviate neurodegenerative diseases like Parkinson’s and Alzheimer’s have always been associated with debilitating side effects. Medicinal mushrooms which harness neuropharmacological compounds may be a promising avenue for protection against such diseases. Panus giganteus (Berk.) Corner has been consumed by the indigenous people in Peninsular Malaysia for many y...

Pleurotus eous is an edible oyster mushroom currently available in Southern part of India. There is no information about the antioxidant and therapeutic properties of this mushroom. Pleurotus eous aqueous extract (PEAE) were prepared and analysed for their antioxidant activity by in vitro assays such as DPPH, hydroxyl radicals, Ferric Thiocyanate (FTC) and Thiobarbituric acid (TBA) test. The ne...

We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large (L) intestinal mucosa. Boiling water extracts from seven species of mushrooms s...