Skeletal muscle blood flow and vascular conductance are influenced by numerous factors that can be divided into two general categories: central cardiovascular control mechanisms and local vascular control mechanisms. Central cardiovascular control mechanisms are thought to be designed primarily for the maintenance of arterial pressure and central cardiovascular homeostasis, whereas local vascul...

Background Myocardial ASL is a technique for the assessment of myocardial blood flow (MBF) without contrast agents. It can be safely applied to patients with end-stage renal disease who are not candidates for first-pass imaging with contrast agents. Myocardial ASL perfusion imaging performed at rest and during adenosine stress provides perfusion reserve (MBFstress/MBFrest), which is a common in...

UNLABELLED The efficacy of cerebral arterial bypass surgery was assessed on brain perfusion SPECT using statistical parametric mapping (SPM) and a probabilistic brain atlas. METHODS Fifteen patients with ischemia in the internal carotid artery (ICA) territory and 21 age-matched healthy volunteers were enrolled. (99m)Tc-HMPAO basal/acetazolamide brain perfusion SPECT was performed 2 wk before ...

Background It has been shown that blood oxygen level dependent (BOLD) cardiac magnetic resonance imaging (CMR) is able to detect myocardial perfusion differences. However, validation of BOLD CMR against myocardial perfusion reserve (MPR) and fractional flow reserve (FFR) is lacking. We sought to analyze the potential diagnostic accuracy of BOLD CMR in comparison to invasively measured FFR which...

BACKGROUND Pressure-induced left ventricular hypertrophy is one of the mechanisms responsible for an impaired coronary vasodilating capacity leading to myocardial ischemia and angina. The aim of the study was to investigate myocardial perfusion using cardiovascular magnetic resonance in patients with arterial hypertension and a history of chest pain and normal coronary angiography, and to estim...

INTRODUCTION: Arterial spin labeling (ASL) is an emerging tool for the assessment of myocardial perfusion and perfusion reserve in humans. This technique requires registration of multiple images and suffers from low signal-to-noise ratio (SNR) [1-4]. In this work, we present a novel approach for mapping perfusion and perfusion reserve based on ASL data. Unregistered spatial data is transformed ...

AIMS Cardiomyopathy produces significant mortality in patients with Friedreich ataxia (FA), a genetic disorder that produces intra-mitochondrial iron accumulation. We sought to test the hypothesis that abnormal myocardial perfusion reserve and fibrosis represent early manifestations of cardiomyopathy. METHODS AND RESULTS Twenty-six patients with genetically proven FA ages 36 ± 12 years withou...

To determine whether coronary vasodilator reserve that persists during myocardial ischemia is present in all left ventricular regions, we measured regional blood flow in 192 left ventricular pieces (mean weight, 201 mg) in each of eight dogs by using radioactive microspheres while perfusing the left main coronary artery at 70, 50, 40, and 30 mm Hg. Flows were measured before and during adenosin...

OBJECTIVES We sought to determine whether myocardial contrast echocardiography (MCE) performed before and early after primary coronary stenting (PCS) in patients with acute myocardial infarction (AMI) could predict recovery of resting left ventricular systolic function and contractile reserve. BACKGROUND Myocardial contrast echocardiography can be used to assess perfusion within the risk area...