background and objective : obstructive sleep apnea (osa) through hypoxia and reoxygenation periods leads to oxidative stress, endothelial dysfunction, and activation of inflammatory cycles, which eventually may cause disorder in vasa nervorum, and peripheral neuropathy in hearing pathway. in this study, we aimed to evaluate the effect of severe sleep apnea on hearing function. materials and met...

RATIONALE Seasonal nadirs in 25-hydroxyvitamin D (25[OH]D) concentrations overlap with increased incidence and severity of obstructive sleep apnea (OSA) in winter. We hypothesized that, because lower 25(OH)D concentrations might lead to upper airway muscle dysfunction, low 25(OH)D would be associated with higher apnea-hypopnea index (AHI), a measure of OSA severity. OBJECTIVES To determine if...

BACKGROUND Beyond obesity, sleep apnea syndrome is frequently associated with excess abdominal adiposity that could contribute to the deteriorated cardiometabolic risk profile of apneic patients. METHODS The present study addressed the respective contribution of the severity of sleep apnea syndrome and excess abdominal adiposity to the cardiometabolic risk profile of 38 non obese men with pol...

introduction: chronic obstructive pulmonary disease (copd) patients are at increased risk of sleep-disorders. the concomitant occurrence of copd and obstructive sleep apnea hypopnea syndrome (osahs) is named overlap syndrome. this study aimed to evaluate the severity of osahs in overlap syndrome patients.materials & methods: this cross-sectional study was conducted on adult patients with forced...

BACKGROUND A link between obstructive sleep apnea and cancer development or progression has been suggested, possibly through chronic hypoxemia, but supporting evidence is limited. We examined the association between the severity of obstructive sleep apnea and prevalent and incident cancer, controlling for known risk factors for cancer development. METHODS We included all adults referred with ...

Introduction:The overlap syndrome, consisting ofobstructive sleep apnea hypopnea syndrome (OSAHS) and chronic obstructvie pulmonary disease (COPD) is a major problem in COPD patients. OSHAS corresponds to the likelihood of systemic hypertension.The present study was aimed to evaluate the association between apnea-hypopnea index and diastolic blood presssure (DBP) in overlap  patients. Materials...

STUDY OBJECTIVES We hypothesized that alterations in cardiac hemodynamics associated with obstructive sleep apnea-hypopnea (OSAH) would be reflected in higher natriuretic peptide levels. We examined the association of OSAH with natriuretic peptides in a community-based sample. DESIGN Cross-sectional, retrospective, observational study. SETTING Framingham Heart Study Offspring Cohort and Sle...

The practical purpose of diagnostic assessment in most cases of obstructive sleep apnea is to predict which patients have symptoms that will improve on treatment. We measured the accuracy with which clinicians make this prediction using polysomnography compared with oximeter-based home monitoring. Patients referred to a sleep center with suspicion of symptomatic obstructive sleep apnea were ran...