The selection of a suitable set of primers is crucial to the multiple PCR (polymerase chain reaction) experiment, which is one of the most important techniques in molecular biology. The minimum primer set (MPS) problem is to minimize the number of primers required to amplify a set of DNA sequences, so that the experimental costs and time will be reduced. However, the MPS problem has been proved...

conclusions molecular assays in the early stages of the disease could help in elucidating the effectiveness of the mbp as a prognostic factor in ms. methods this study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental). a novel methodology combining molecular techniques was used to confirm the antigenic properties of mbp and study its ...

conclusions the results suggested that apr1 gene expression in c. albicans strains isolated from ms patients may be an important factor for invasive c. albicans strains in the progression of ms disease. results there was a statistically significant difference in apr1 gene expression of c. albicans strains between ms patients (mean ± sd: 0.5208 ± 0.11518) and the control group (mean ± sd: 0.7603...

background: multiple myeloma (mm) is a disease of plasma cells that has fatal consequences. new agents associated with mo­lecular targets have prompted clinical investigators to design new treatment strategies initially for advanced mm and later for newly diagnosed mm, with encouraging preliminary results.  we devised a project to assess the mechanisms of ac­tion of two drugs, ar­senic trioxide...