Dear Editor-in-Chief   Pilomatrixoma is a benign tumor of hair follicle first described as calcifying epithelium (1). It accounts for 1% of all the benign skin tumors (2). It is a slow-growing, firm, dermal or subcutaneous neoplasm, usually measuring fewer than 3 cm in diameter. Pilomatricomas are considered benign; rarely recur after surgical excisi...

Adult stem cells are multipotent and can be induced experimentally to differentiate into various cell lineages. Such cells are therefore a key part of achieving the promise of tissue regeneration. The most studied stem cells are those of the hematopoietic and mesenchymal lineages. Recently, mesenchymal stem cells were demonstrated in dental tissues, including dental pulp, periodontal ligament, ...

Calcifying epithelial odontogenic tumour (Pindborg tumour) is a rare benign neoplasm with a poorly understood histogenesis. This report describes a single case of a maxillary calcifying epithelial odontogenic tumour including immunohistochemical analysis. The vast majority of tumour cells were positive for CK5/6 and p63. Furthermore, basal cells also displayed moderate reaction for vimentin and...

Pilomatricoma was first described in 1880 by Malherbe as a calcifying epithelioma, but this later changed to benign tumour arising from the hair follicle matrix cells. It typically presents firm, painless well-circumscribed mass children. They are most commonly found head and neck, particularly peri-auricular area. slow growing asymptomatic, generally appearing solitary multiple lesions can be ...

Malherbe and Chenantais were the first to report a pilomatrixoma in 1880. They described a calcifying epithelioma, believing it to be a sebaceous gland tumor. Since 1905, this uncommon neoplasia has been called Malherbe’s calcifying epithelioma. Numerous studies suggest that this tumor stems from the external sheath of hair follicles. In 1961, Forbis and Helwig proposed the term pilomatrixoma, ...

Pilomatrixoma is a benign tumor of hair follicle first described as calcifying epithelium (1). It accounts for 1% of all the benign skin tumors (2). It is a slow-growing, firm, dermal or subcutaneous neoplasm, usually measuring fewer than 3 cm in diameter. Pilomatricomas are considered benign; rarely recur after surgical excision (3). However, cases of pilomatrixoma with local recurrence and lo...

Purpose: To examine osteoblastic genes expression of freshly isolated human dental follicle cells during osteogenic differentiation in vitro using cDNA microarrays. Materials and Methods: The dental follicle cells isolated from dental follicle were cultured in DMEM media with 10 mol/L Dex for 4 weeks, the control without Dex. Total RNA was extracted from the cultured follicle cells with Trizol....

STATEMENT OF THE PROBLEM The presence of impacted third molars in the jaws is a common finding in the routine dental examination of patients. Concerning the odontogenic components of the dental follicle, it can be the origin of different types of odontogenic cysts and tumors. PURPOSE The aim of this study was to find feasible radiographic criteria to help differentiate between normal and path...

Dental follicle stem cells are a group of cells possessing osteogenic, adipogenetic and neurogenic differentiations, but the specific mechanism underlying the multilineage differentiation remains still unclear. Great attention has been paid to bone morphogenetic protein-9 (BMP-9) due to its potent osteogenic activity. In the present study, rat dental follicle stem cells were isolated and purifi...

An impacted left mandibular second molar (tooth 37) was extracted, but most of its dental follicle remained in the socket. The crown and dental papilla of an unerupted, left mandibular third molar (tooth 38) were then placed into the socket of tooth 37. Successful interaction between the dental follicle of tooth 37 and the crown and dental papilla of tooth 38 led to the formation of a new tooth...