Machine learning models trained with experimental data for antimicrobial activity and hemolysis are shown to produce new non-hemolytic peptides active against multidrug-resistant bacteria.

in the last decade, along with the problem of nosocomial infections, multidrug-resistant bacteria in community and hospitals have soared. high frequencies of multidrug-resistant bacteria have been grouped under the acronym eskape: enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa and enterobacter spp. the eskape pathogens are res...

the resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. infection of drug-resistance bacteria seriously threatens human health. currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. in this paper, a series of (s,z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent se...

many classes of antibacterial drugs are currently available for physicians to use, however the plan of antibiotic development has slowed during the last decade. the world health organization (who) has identified antimicrobial resistance as one of the 3 most important problems for human health. antimicrobial resistance is a growing problem worldwide, especially in hospitals, where resistant orga...

    In conclusion, UTI is a globally distributed disease with emergence of multidrug-resistant bacteria; thus, new drug discovery or activation of previously used drugs is an urgent issue. Methenamine has been suggested as a beneficial agent for the UTI prevention as it works as a urinary antiseptic by safely producing formaldehyde to prevent bacterial growth while avoiding bacterial resistance...

Nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. In view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

Background: The spread of resistant bacteria has caused serious concern worldwide. multidrug-resistant (MDR) and extensive drug-resistant (XDR) limits the choice antibiotics, making available antibiotics less effective. Objectives: This study aimed to investigate resistance patterns seven global threatening organisms announced by Centers for Disease Control Prevention (CDC) one year in Iran, ca...

Mobile phones and stethoscopes used in neonatology units could be colonized by potentiel bacteria pathogens. It can be a vector of severe nosocomial infections and multi-drug-resistant pathogens. The aim of this study is to evaluate the microbial contamination of mobile phones and stethoscopes, used by medical and paramedical staff. The study was conducted in neonatal intensive care unit (NICU)...