background and objectives: β-lactamase production is the predominant mechanism for resistance to β-lactams in enterobacteriaceae. the producing isolates are often multidrug resistant and are major hosts for extended spectrum β-lactamases. this study was designed to determine the prevalence of extended-spectrum β-lactamase producing isolates of escherichia coli and klebsiella pneumoniae and thei...

multidrug resistance (mdr) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. nevertheless, in most drug resistant cell lines and cancer patients up-regulation of abc-transporter genes such as mdr associated protein (mrp1) gene could be at the basis of the drug resistance phenotype. we aimed to decre...

target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in pseudomonas aeruginosa. we performed a genotypic characterization of three major mex multidrug efflux pumps (mexab-oprm, mexxy-oprm and mexcd-oprj) in ciprofloxacin resistant clinical isolates of p. aeru­ginosa, collected from tehran, iran this was followed by sequencing a...

conclusions the hai prevalence found in this study was lower than hai rates reported in some other studies from iran. the isolates showed high resistance to common antibiotics. guidelines for improving hai surveillance and stringent measures to reduce the prevalence of multidrug-resistant hais must be implemented to reduce the rate and the consequences of hais. results a total of 16,140 patient...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

Multidrug resistance can be induced in mammalian cells by selection with a single cytotoxic agent. Overproduction of the energy-dependent drug efflux pump P-glycoprotein, encoded by the mdr1 gene, has been identified as the cause of one form of multidrug resistance. The molecular basis of other forms of multidrug resistance is unknown. Doxorubicin selection of the human squamous lung cancer cel...

Multidrug resistance can be induced in mammalian cells by selection with a single cytotoxic agent. Overproduction of the energy-dependent drug efflux pump P-glycoprotein, encoded by the mtlrl gene, has been identified as the cause of one form of multidrug resistance. The molec ular basis of other forms of multidrug resistance is unknown. Doxorubicin selection of the human squamous lung cancer c...

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

results the isolates were completely resistant to the tested antibiotics, with minimum inhibitory concentration (mic) values for ceftazidime, imipenem, and gentamicin between 256 to > 256 μg/ml, 8 to > 256 μg/ml, and 64 to > 256 μg/ml, respectively. the r. dentatus extract had a broad spectrum activity against all tested isolates and maximum growth inhibition against isolates from burn wound an...