[6] or related to progressive destruction of the base of the distal phalanx by the rheumatoid process [1]. Acro-osteolysis has also been reported after trauma, burns, frostbite or neuropathic disorders such as insensitivity to pain and tarsal tunnel syndrome. It has also been observed in systemic diseases such as sarcoidosis, diabetes mellitus, renal diseases and hyperparathyroid-ism. Vascular ...

Inherited Multicentric Osteolysis (IMO) is an uncommon familial condition of idiopathic pathophysiology causing bone osteolysis and dysplasia. These patients present with common rheumatologic complaints of pain, dysfunction and disability, and are often initially misdiagnosed as a chronic rheumatic disease of childhood such as juvenile idiopathic arthritis. We report a case of three siblings di...

Osteolysis is defined as destruction of bone by resorption. Usually this resorption is associated with some underlying disorder and classified as secondary osteolytic syndromes. Primary idiopathic osteolysis is rare. It is characterised by the spontaneous onset of bone resorption without known causative factors. Bones which previously appeared normal begin to undergo partial or complete resorpt...

Multicentric osteolysis, nodulosis, and arthropathy (MONA) syndrome is one of the rare genetic skeletal dysplasias, inherited as an autosomal recessive disorder, which predominantly involves carpal tarsal bones with characteristic osteolytic lesions can be misdiagnosed juvenile idiopathic arthritis or rheumatoid arthritis. MONA includes diseases involving two genes: matrix metalloproteinase 2 (...

Torg and Winchester syndromes and patients reported by Al-AqeelSawairi as well as nodulosis-arthropathy-osteolysis (NAO) patients, patients with multicentric NAO share autosomal recessive inheritance. The common presenting symptomatology includes progressive osteolysis chiefly affecting the carpal, tarsal and interphalangeal joints. Here, we report a patient with Torg syndrome. Torg syndrome is...