Liquid crystalline systems of glyceryl monooleate/water are used as drug delivery due to their complex structure that controls diffusion. Mucoadhesive properties monooleate suggest it can be for buccal delivery. Using additives is a strategy modify physical and chemical liquid optimize performance system. However, the presence significantly alter such phase behavior, swelling mucoadhesion. Our ...

BACKGROUND Periodontitis is a disease of tooth supporting tissues, and Gram-negative Bacteria are the main cause of this. Propolis has antibacterial, anti-inflammatory, and antioxidant effects due to its high polyphenol and flavonoids content. The aim of this study is the formulation of a mucoadhesive gel containing concentrated extract of propolis for treatment of periodontitis. MATERIALS AN...

In order to formulate an efficient and durable mucoadhesive drug delivery system, careful consideration of formulation-related parameters is critical. This study was conducted to investigate the effect of the presence of various types and concentrations of surfactants within or outside Carbopol 934 (C934) as well as hydroxypropylmethyl cellulose (HPMC) solid compacts, on their duration of mucoa...

In order to formulate an efficient and durable mucoadhesive drug delivery system, careful consideration of formulation-related parameters is critical. This study was conducted to investigate the effect of the presence of various types and concentrations of surfactants within or outside Carbopol 934 (C934) as well as hydroxypropylmethyl cellulose (HPMC) solid compacts, on their duration of mucoa...

Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere to the oral mucosa are advantageous as they could increase the effectiveness of the therapy. Positively, negatively and neutrally charged liposomes were coated with four dif...

Mucoadhesive buccal patches containing propranolol hydrochloride were prepared using the solvent casting method. Chitosan was used as bioadhesive polymer and different ratios of chitosan to PVP K-30 were used. The patches were evaluated for their physical characteristics like mass variation, drug content uniformity, folding endurance, ex vivo mucoadhesion strength, ex vivo mucoadhesion time, su...

Objective: The objective of this study was to formulate and evaluate sustained release gastro retentive microspheres of furosemide using mucoadhesive polymers. It was expected that gastro retention plus mucoadhesion would contribute to extending the rate of drug release in the acidic medium in vitro, thereby projecting this formulation as a potential candidate for improvement of oral bioavailab...

The purpose of research work was to develop and optimize mucoadhesive microspheres of glibenclamide incorporated in in-situ gel for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy. Chitosan (mucoadhesive) based microspheres of glibenclamide were prepared by emulsificationcrosslinking method. Glutaraldehyde was used as crosslinking agent. A 32 factorial...

OBJECTIVE S Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease. MATERIALS AND METHODS Every discs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitr...