BACKGROUND Ginger is one of the most important spice crops and traditionally has been used as medicinal plant in Bangladesh. The present work is aimed to find out antioxidant and anticancer activities of two Bangladeshi ginger varieties (Fulbaria and Syedpuri) at young age grown under ambient (400 μmol/mol) and elevated (800 μmol/mol) CO2 concentrations against two human breast cancer cell line...

The presence of phenolic compounds in fruit- and vegetable-rich diets has attracted researchers' attention due to their health-promoting effects. The objective of this study was to evaluate the effects of purple pitanga (Eugenia uniflora L.) extract on cell proliferation, viability, mitochondrial membrane potential, cell death and cell cycle in murine activated hepatic stellate cells (GRX). Cel...

Introduction: A bis-chalcones were prepared by the reaction of terephthalaldehyde with 3-acetyl-2,5-dichlorothiophene or 3-acetyl- 5-chlorothiophene and cyclo ketone derivatives phenyl aldehyde in good yields.
 Methods: The molecular docking studies conducted using Discovery Studio (DSv4.5) MG. Tools installed Window 10. cancer receptor (3ERT) was downloaded from protein data bank (PDB). A...

Purpose: To investigate the involvement of aldo-keto reductase family 1 member C1 (AKR1C1) in glycyrrhizic acid-mediated gastric cancer.Methods: Immunohistochemistry, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and western blot were used to assess AKR1C1 expression cancer. Cell proliferation was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-te...

Tetrazolium salts like 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) or sodium 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) that form formazans after reduction are widely used to investigate cell viability. Besides cellular enzymes, some constituents of cell media and other substances reduce tetrazolium salts, thereby interfering with t...

OBJECTIVES Chrysin, an active natural bioflavonoid found in honey and many plant extracts, was first known for its antioxidant and anti-inflammatory effects. The fact that antioxidants have several inhibitory effects against different diseases, such as cancer, led to search for food rich in antioxidants. In this study, we investigated the antiproliferative and apoptotic effects of chrysin on th...

Houttuynia cordata Thunb. is an edible and medicinal plant that belongs to the family of Saururaceae widely distributes in Eastern Asia countries. H. have been reported as a promising anticancer agent against various cancer cells. This study was determine anti-proliferative effect extract on gastric cells using vitro experimental model. The cytotoxicity examined via 2,5-diphenyl-2H-tetrazolium ...


 Purpose: To determine the antitumor effect of demethoxycurcumin on lung cancer cells, as well its PI3K/AKT/m-TOR signalling, cellular apoptosis, cell migration and invasion.
 Methods: Cell viability was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, while AO/EB annexin V/PI staining assays were used for apoptosis analysis in demethoxycurc...

: This study aimed to evaluate the chemical composition and anticancer activity of Hamadan propolis essential oil methanolic extract on HCT116 cell line. The was evaluated by using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) test colorectal analyzed gas chromatography-flame ionization detection (GC-FID) chromatography-mass spectrometry (GC-MS). total flavonoid phenoli...

Plant-based compounds have been used for medicinal purposes since ancient times, as easily accessible and low-cost treatment options. Despite the widespread belief that plants are quite safe devoid of side effects, scientific studies revealed toxicity potential active components on healthy cells. The present study was designed to investigate in vitro cytotoxicity genotoxicity Achillea wilhelmsi...