نتایج جستجو برای: mtor
تعداد نتایج: 16868 فیلتر نتایج به سال:
The mechanistic/mammalian target of rapamycin (mTOR) is considered to be an atypical protein kinase that plays a critical role in integrating different cellular and environmental inputs the form growth factors, nutrients energy and, subsequently, regulating events, including cell metabolism, survival, homeostasis, differentiation. Immunologically, mTOR regulator immune function through numerous...
1 S*BIO Pte Ltd, 1 Science Park Road, Singapore 117528, Singapore 2 Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore, 3 Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Singapore 119228, Singapore. Massachusetts Gene...
It has been shown that mammalian target of rapamycin (mTOR) inhibitors activate Akt while inhibiting mTOR signaling. However, the underlying mechanisms and the effect of the Akt activation on mTOR-targeted cancer therapy are unclear. The present work focused on addressing the role of mTOR/rictor in mTOR inhibitor-induced Akt activation and the effect of sustained Akt activation on mTOR-targeted...
PURPOSE mTOR is a validated target in cancer. It remains to be determined whether melanoma patients bearing mTOR mutation could be selected for treatment with PI3K-AKT-mTOR pathway inhibitors. EXPERIMENTAL DESIGN A total of 412 melanoma samples were included. Gene aberrations in all exons of mTOR were detected by Sanger sequencing and confirmed by using Agilent's SureSelect Target Enrichment ...
The altered expression and activation of the mammalian target of rapamycin (mTOR) promotes the invasiveness and metastatic potential in a variety of malignancies. The aim of the present pilot study was to determine mTOR expression in clear cell renal cell carcinoma (RCC) and to evaluate mTOR activation and phosphorylation at Ser2448. Tissue microarray immunohistochemistry and Western blot analy...
Objective(s): Zinc is an effective factor in the reproductive system. Insulin resistance (IR) is known as an important disorder in patients with polycystic ovary syndrome (PCOS). Mammalian target of rapamycin (mTOR), which controls key cell activities, in particular, is activated in disorders such as PCOS. The present study was conducted to observe the therapeutic effe...
Background: The pathway of mTORC1 is one of the most important pathway in protein synthesis, and type 2 diabetes and insulin resistance can lead to inhibit this pathway. The aim of this study was to investigate the effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways in gastrocnemius muscle in type 2 diabetic rats. Materials and met...
Introduction: The mTOR and SREBP1 proteins play an important role important in the regulation and metabolism of adipose tissue that can be activated through the mTORC1 pathway. The purpose of the present study was to investigate the effect of 8 weeks endurance training on the content of mTOR and SREBP1 proteins in subcutaneous fat tissue in obese type 2 diabetic male Sprague-Dawley rats. Metho...
Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been characterized in MTOR, the gene encoding the mTOR kinase. Using publicly available tumor genome sequencing data, we generated a comprehensive catalog of mTOR pathway mutations in cancer, identifying 33 MTOR mutations that confer pathway hyperactivation. The mutations clust...
Background: The mTORC1 pathway is one of the important pathways for protein synthesis in the heart, which can lead to physiological or pathological hypertrophy. Diabetes can lead to defects in this pathway. The aim of this study was to examine the effect of 4 weeks’ aerobic training on the content of mTORC1 signaling pathway proteins in heart tissue of type 1 diabetes rats. Methods: In this ...
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