Background: Sleep disorder, frequently observed among perimenopausal women, decreases quality of life. Melatonin is reported to ameliorate circadian imbalances and thus can be employed as a treatment for sleep disorder patients. We attempted clarify whether how melatonin affects disorders. Methods: Study patients consisted 120 women divided into 3 groups: (i) without (n = 60); (ii) those with b...

melatonin regulates some major physiological processes such as maturation and function of reproductive system, pubertal development, seasonal reproduction and adaptation. the activation of melatonin hormone is mediated by melatonin receptor. previous studies showed melatonin receptor 1a gene (mtnr1a) is highly polymorphic in seasonally breeding species. the aim of the present study was detectio...

Melatonin receptors are members of the G protein-coupled receptor (GPCR) family. Three genes for melatonin receptors have been cloned. The MT1 (or Mel1a or MTNR1A) and MT2 (or Mel1b or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype, Mel1c (or MTNR1C), has been identified in fish, amphibians and birds. Another melatonin related o...

Piwi-associated RNAs (piRNAs) are a distinct class of 24- to 30-nucleotide-long RNAs produced by a Dicer-independent mechanism, and are associated with Piwi-class Argonaute proteins. In contrast to the several hundred species of microRNAs (miRNAs) identified thus far, piRNAs consist of more than 30,000 different species in humans. Studies in flies, fish and mice implicate these piRNAs in regula...

Epidemiologic and animal studies indicate that disruption of circadian rhythm increases breast cancer risk. Previously, we showed that methylselenocysteine reduced the incidence of N-nitroso-N-methylurea (NMU)-induced mammary carcinomas in Fischer 344 rats by 63%. Methylselenocysteine also increased the expression of Period 2 (Per2) and D-binding protein (DBP), providing evidence for a link bet...

Previous studies have documented that both vitamin D deficiency and single nucleotide polymorphism (SNPs) of genes responsible for mediating downstream effects melatonin with development breast cancer. In India 70 percent the population suffers from Vitamin deficiency. There are no available reports on association SNPs in Melatonin towards cancer Indian population. To this end, we evaluated 50 ...

Melatonin regulates some major physiological processes such as maturation and function of reproductive system, pubertal development, seasonal reproduction and adaptation. The activation of melatonin hormone is mediated by melatonin receptor. Previous studies showed melatonin receptor 1A gene (MTNR1A) is highly polymorphic in seasonally breeding species. The aim of the present study was detectio...

Remarkable seasonal variations are observed in the reproductive activities of small ruminants living in temperate latitudes (Luridiana et al. 2015). Thus, a great alteration is induced by lamb reproductive seasonality and its consequent meat market price. Alternatively, out-of-season reproduction is induced through a wide use of hormonal treatments in some countries. However, there is a need fo...