All ribosomal protein (rp) gene promoters from Saccharomyces cerevisiae studied so far contain either (usually two) binding sites for the global gene regulator Rap1p or one binding site for another global factor, Abf1p. Previous analysis of the rpS33 and rpL45 gene promoters suggested that apart from the Abf1 binding site, additional cis-acting elements play a part in transcription activation o...

Abstract Introduction There remains a paucity of novel therapeutics for limb salvage in patients with critical ischemia (CLI) whom revascularization procedures have failed and amputation is imminent. We shown that E-selectin+/Mesenchymal Stem Cell (MSC) injections into the ischemic tissue CLI mouse model improves function. Thus, we sought to determine mechanism action E-selectin+/MSC’s pro-angi...

Background: Due to oxidative stress, hypoxia, and serum deprivation, a large percentage of mesenchymal stem cells (MSCs) die in the early stages of transplantation. The present study aimed to address whether induction or inhibition of autophagy would affect the viability of MSCs after exposure to oxidative stress.Methods: MSCs were isolated from umbilical cord tissue using the Ficoll grad...

We consider a spectrum of geometric optimization problems motivated by contexts such as satellite communication and astrophysics. In the problem Minimum Scan Cover with Angular Costs , we are given graph G that is embedded in Euclidean space. The edges need to be scanned, i.e., probed from both their vertices. To scan edge, two vertices face each other; changing heading vertex incurs some cost ...

Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC−/− showed elevated cytokines with severer pathology, reduced body weight, earlier death. Reversal of colitis symptoms by IL-22 antagonism suggests the existence MSC:IL-22 regulatory axis.

auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. in the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...

Nanovesicles In article 2300315 by Jiacan Su, Meng Li, Jie Gao, and co-workers, GelMA-NVs, defined as gelatin methacryloyl hydrogels loaded with exosome-mimicking mesenchymal stem cell-derived nanovesicles (MSC-NVs), exhibit sustained release of MSC-NVs which could increase chondrocyte human bone marrow MSC differentiation, proliferation, migration induce M2 macrophage polarization.