OBJECTIVE To evaluate the incidence of adverse cutaneous drug reactions in intensive care unit patients. DESIGN Cohort study. SETTING General adult intensive care unit of an institutional tertiary care hospital. PATIENTS Patients in the intensive care unit during a consecutive 8-month period were examined for adverse cutaneous drug reactions. RESULTS Patients in the intensive care unit ...

Human parvovirus B19 replicates in erythrocyte precursors. Usually, there are no apparent hematological manifestations. However, in individuals with high erythrocyte turnover, as in patients with sickle-cell disease and in the fetus, the infection may lead to severe transient aplasia and hydrops fetalis, respectively. In AIDS patients, persistent infection may result in chronic anemia. By contr...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, potentially life-threatening idiosyncratic drug reaction that may result in skin eruption, mucous membrane involvement, eosinophilia, atypical lymphocytosis and lymphadenopathy, with wide-ranging internal organ involvement. The authors report the case of a 21-year-old man who was prescribed lamotrigine for anxiety disord...

CASE REPORT A 76-year-old white woman presented with a 3-month history of a pruritic, diffuse morbilliform eruption consisting of erythematous papules and plaques with cigarette-paper scale coalescing to cover more than 80% body surface area (Fig 1). Based on clinical presentation, the initial differential diagnosis included a drug eruption or urticarial bullous pemphigoid. The patient’s amlodi...

COVID-19 can affect multiple organs, including skin. A wide range of skin manifestations have been reported in literature. Six main phenotypes identified: i) urticarial rash, ii) confluent erythematous/maculopapular/morbilliform iii) papulovesicular exanthem, iv) a chilblain-like acral pattern, v) livedo reticularis/racemosa-like and vi) purpuric vasculitic pattern. The pathogenetic mechanism i...

OBJECTIVE Cardiac involvement in drug rash with eosinophilia and systemic symptoms (DRESS) syndrome varies considerably between 4% and 21%. Here we present our case and review literatures for its diagnosis and management. An algorithm for diagnosis of cardiac involvement in DRESS syndrome is proposed in this article. DATA SOURCES Data regarding DRESS-associated myocarditis and eosinophilic my...

results: a total number of 117 patients were evaluated for adverse drug reactions, among them, 97 (82.9%) were considered to have immunological drug reactions. the most common symptoms of allergic drug reactions were morbilliform eruptions, serum sickness, dress (drug rash with eosinophilia and systemic symptoms), and toxic epidermal necrolysis. in 62 patients, anticonvulsant drugs had the prom...

Case 1 B.W.P. (39175), a boy of 6, in December 1965 developed prolonged intermittent fever and 2 months later was admitted to another hospital with abdominal pain, lymphadenopathy and a morbilliform rash, later scaling. Skin oedema and hair fall followed. He was started on prednisone but by May 1956 generalized oedema was present: he had lost weight and had difficulty in walking. He was admitte...

Pegylated or non-pegylated α-interferon are frequently used medications for the treatment of both chronic hepatitis B and chronic hepatitis C. Skin disorders, which are mainly comprised of eczematous dermatitis, are frequently seen during treatment with this drug. However, drug eruption or morbilliform eruptions due to interferons have been rarely reported so far. We herein describe a patient w...